Serum C-X-C motif chemokine ligand 9, interleukin 8, and interleukin 22 as key biomarkers in pediatric inflammatory bowel disease

doi:10.3748/wjg.v31.i46.113172

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Dec 14, 2025; 31(46): 113172
Published online Dec 14, 2025. doi: 10.3748/wjg.v31.i46.113172

Table 4 Univariate analysis of biomarker intensities: Comparison of biological treatment initiation by 1 year

	No biologic treatment (n = 75)	Biologic treatment (n = 48)	P value
Female, n (%)	33 (44.0)	12 (25.0)	0.052
Ethnicity, n (%)			0.56
Western European	50 (66.7)	34 (70.8)
South Asian	13 (17.3)	5 (10.4)
Other	12 (16.0)	9 (18.8)
Age (year)	13.0 ± 3.07	12.5 ± 2.39	0.353
Biomarker
CCL2	104 ± 37.1	105 ± 54.1	0.937
CCL5	1722 ± 770	1798 ± 1479	0.742
CCL7	283 ± 138	269 ± 108	0.532
IL-8	40.5 ± 217	15.1 ± 13.4	0.316
TSLP	308 ± 106	286 ± 128	0.323
CCL3	44.2 ± 11.9	46.2 ± 17.3	0.498
CXCL1	297 ± 257	415 ± 330	0.039
CXCL2	176 ± 204	241 ± 201	0.083
CXCL9	4087 ± 3470	4102 ± 2828	0.979
IL-18	137 ± 123	214 ± 280	0.08
IL-22	64.9 ± 233	43.8 ± 16.0	0.438
TARC	379 ± 641	288 ± 146	0.238

CCL: C-C motif ligand; CXCL: C-X-C motif chemokine ligand; IL: Interleukin; TARC: Thymus and activation-regulated chemokine; TSLP: Thymic stromal lymphopoietin.

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Citation: Eindor-Abarbanel A, Tsai K, Sandhu A, Vallance B, Jacobson K. Serum C-X-C motif chemokine ligand 9, interleukin 8, and interleukin 22 as key biomarkers in pediatric inflammatory bowel disease. World J Gastroenterol 2025; 31(46): 113172
URL: https://www.wjgnet.com/1007-9327/full/v31/i46/113172.htm
DOI: https://dx.doi.org/10.3748/wjg.v31.i46.113172

Eindor-Abarbanel A, Tsai K, Sandhu A, Vallance B, Jacobson K. Serum C-X-C motif chemokine ligand 9, interleukin 8, and interleukin 22 as key biomarkers in pediatric inflammatory bowel disease. World J Gastroenterol 2025; 31(46): 113172 [PMID: 41479641 DOI: 10.3748/wjg.v31.i46.113172]

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