Serum C-X-C motif chemokine ligand 9, interleukin 8, and interleukin 22 as key biomarkers in pediatric inflammatory bowel disease

doi:10.3748/wjg.v31.i46.113172

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Dec 14, 2025; 31(46): 113172
Published online Dec 14, 2025. doi: 10.3748/wjg.v31.i46.113172

Table 3 Univariate analysis of biomarker intensities: Comparison of Crohn's disease vs ulcerative colitis, mean ± SD

	CD (n = 103)	UC (n = 46)	P value
Female, n (%)	32 (31.1)	21 (45.7)	0.125
Ethnicity, n (%)			0.02
Western European	77 (74.8)	25 (54.3)
South Asian	9 (8.74)	11 (23.9)
Other	17 (16.5)	10 (21.7)
Age (year)	12.5 ± 2.71	13.6 ± 3.07	0.031
Biomarker
CCL2	97.0 ± 36.8	111 ± 52.6	0.113
CCL5	1643 ± 1139	1624 ± 665	0.897
CCL7	259 ± 144	245 ± 111	0.501
IL-8	33.2 ± 186	14.4 ± 9.54	0.307
TSLP	268 ± 119	290 ± 130	0.325
CCL3	45.7 ± 15.5	43.9 ± 9.96	0.399
CXCL1	318 ± 253	385 ± 353	0.248
CXCL2	193 ± 155	203 ± 261	0.814
CXCL9	4468 ± 3433	3171 ± 2763	0.016
IL-18	190 ± 218	128 ± 91.0	0.016
IL-22	59.5 ± 199	40.2 ± 16.9	0.331
TARC	293 ± 180	403 ± 802	0.362

CCL: C-C motif ligand; CD: Crohn's disease; CXCL: C-X-C motif chemokine ligand; IL-8: Interleukin 8; TSLP: Thymic stromal lymphopoietin; UC: Ulcerative colitis.

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Citation: Eindor-Abarbanel A, Tsai K, Sandhu A, Vallance B, Jacobson K. Serum C-X-C motif chemokine ligand 9, interleukin 8, and interleukin 22 as key biomarkers in pediatric inflammatory bowel disease. World J Gastroenterol 2025; 31(46): 113172
URL: https://www.wjgnet.com/1007-9327/full/v31/i46/113172.htm
DOI: https://dx.doi.org/10.3748/wjg.v31.i46.113172

Eindor-Abarbanel A, Tsai K, Sandhu A, Vallance B, Jacobson K. Serum C-X-C motif chemokine ligand 9, interleukin 8, and interleukin 22 as key biomarkers in pediatric inflammatory bowel disease. World J Gastroenterol 2025; 31(46): 113172 [PMID: 41479641 DOI: 10.3748/wjg.v31.i46.113172]

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