Serum C-X-C motif chemokine ligand 9, interleukin 8, and interleukin 22 as key biomarkers in pediatric inflammatory bowel disease

doi:10.3748/wjg.v31.i46.113172

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Dec 14, 2025; 31(46): 113172
Published online Dec 14, 2025. doi: 10.3748/wjg.v31.i46.113172

Table 1 Univariate analysis of biomarker intensities: Comparison of inflammatory bowel disease vs non-inflammatory bowel disease patients, mean ± SD

Biomarker	IBD (n = 155)	Non-IBD (n = 91)	P value
CCL2	101 ± 42.9	108 ± 43.7	0.239
CCL5	1650 ± 1010	1710 ± 665	0.526
CCL7	249 ± 135	244 ± 120	0.761
IL-8	27.1 ± 151	8.93 ± 4.63	0.138
TSLP	269 ± 123	265 ± 132	0.812
CCL3	45.6 ± 15.7	44.0 ± 13.1	0.409
CXCL1	347 ± 289	306 ± 275	0.267
CXCL2	200 ± 197	196 ± 225	0.892
CXCL9	3980 ± 3250	1440 ± 1460	< 0.001
IL-18	169 ± 187	134 ± 216	0.204
IL-22	52.8 ± 163	31.9 ± 13.6	0.113
TARC	326 ± 461	331 ± 241	0.913

IBD: Inflammatory bowel disease; CCL: C-C motif ligand; CXCL: C-X-C motif chemokine ligand; IL: Interleukin; TARC: Thymus and activation-regulated chemokine; TSLP: Thymic stromal lymphopoietin.

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Citation: Eindor-Abarbanel A, Tsai K, Sandhu A, Vallance B, Jacobson K. Serum C-X-C motif chemokine ligand 9, interleukin 8, and interleukin 22 as key biomarkers in pediatric inflammatory bowel disease. World J Gastroenterol 2025; 31(46): 113172
URL: https://www.wjgnet.com/1007-9327/full/v31/i46/113172.htm
DOI: https://dx.doi.org/10.3748/wjg.v31.i46.113172

Eindor-Abarbanel A, Tsai K, Sandhu A, Vallance B, Jacobson K. Serum C-X-C motif chemokine ligand 9, interleukin 8, and interleukin 22 as key biomarkers in pediatric inflammatory bowel disease. World J Gastroenterol 2025; 31(46): 113172 [PMID: 41479641 DOI: 10.3748/wjg.v31.i46.113172]

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