IGF2BP3 binds to FBXO32 to activate the cyclic guanosine monophosphate-protein kinase G pathway, promoting gastric cancer progression

doi:10.3748/wjg.v31.i46.111631

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Dec 14, 2025; 31(46): 111631
Published online Dec 14, 2025. doi: 10.3748/wjg.v31.i46.111631

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Figure 8 Schematic illustration of the molecular mechanism of IGF2BP3 in gastric cancer. pGC: Particulate guanylyl cyclase; sGC: Soluble guanylyl cyclase; GTP: Guanosine triphosphate; cGMP: Cyclic guanosine monophosphate; PKG: Protein kinase G; p-VASP: Phospho-VASP; mRNA: Messenger RNA; m⁶A: N⁶-methyladenosine.

Citation: Si Y, Tian B, Zhang R, Xuan MD, Liu KY, Jiao J, Han SS, Li HF, Hu YH, Zhao HY, He WJ, Wang J, Liu T, Yu WF. IGF2BP3 binds to FBXO32 to activate the cyclic guanosine monophosphate-protein kinase G pathway, promoting gastric cancer progression. World J Gastroenterol 2025; 31(46): 111631
URL: https://www.wjgnet.com/1007-9327/full/v31/i46/111631.htm
DOI: https://dx.doi.org/10.3748/wjg.v31.i46.111631

Si Y, Tian B, Zhang R, Xuan MD, Liu KY, Jiao J, Han SS, Li HF, Hu YH, Zhao HY, He WJ, Wang J, Liu T, Yu WF. IGF2BP3 binds to FBXO32 to activate the cyclic guanosine monophosphate-protein kinase G pathway, promoting gastric cancer progression. World J Gastroenterol 2025; 31(46): 111631 [PMID: 41479643 DOI: 10.3748/wjg.v31.i46.111631]

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