Clinical characteristics and risk factors of refractory gastroesophageal reflux disease: A multicenter cross-sectional study

doi:10.3748/wjg.v31.i45.113060

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Dec 7, 2025; 31(45): 113060
Published online Dec 7, 2025. doi: 10.3748/wjg.v31.i45.113060

Table 5 Correlation analysis between exercise and other relevant variables

Variable	Exercise
Variable	r/χ² value	P value
Esophageal chest pain	-0.158	0.011^a
Eating beyond fullness	0.265	0.607
Sensation of pharyngeal obstruction	0.006	0.939
Constipation	0.330	0.566
Disease duration	-0.013	0.831
SSS-CN score	-0.016	0.805
HADS-A score	-0.163	0.009^b
HADS-D score	-0.161	0.010^a
GERD-HRQL score	-0.224	< 0.001^c

^aP < 0.05.

^bP < 0.01.

^cP < 0.001.

SSS-CN: Somatic symptom scale-China; HADS-A: Hospital anxiety and depression scale-anxiety; HADS-D: Hospital anxiety and depression scale-depression; GERD-HRQL: Gastroesophageal reflux disease health-related quality of life.

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Citation: Zhang N, Wang Y, Fang SS, Han M, Zheng QW, Zhu YY, Zhang MY, Li JJ, Cui LX, Tian JL, Deng YH, Zhu SL, Ni HM, Zhou L, Zuo GL, Huang TS, Liao Q, Li XQ, Shang YY, Wang YJ, Tian Y, Ge LY, Han HQ, Hu WM, Jiang Y, Li YJ, Mao X, Yang LH, Yao JM, Zheng X, Wang HW, Fang SQ. Clinical characteristics and risk factors of refractory gastroesophageal reflux disease: A multicenter cross-sectional study. World J Gastroenterol 2025; 31(45): 113060
URL: https://www.wjgnet.com/1007-9327/full/v31/i45/113060.htm
DOI: https://dx.doi.org/10.3748/wjg.v31.i45.113060

Zhang N, Wang Y, Fang SS, Han M, Zheng QW, Zhu YY, Zhang MY, Li JJ, Cui LX, Tian JL, Deng YH, Zhu SL, Ni HM, Zhou L, Zuo GL, Huang TS, Liao Q, Li XQ, Shang YY, Wang YJ, Tian Y, Ge LY, Han HQ, Hu WM, Jiang Y, Li YJ, Mao X, Yang LH, Yao JM, Zheng X, Wang HW, Fang SQ. Clinical characteristics and risk factors of refractory gastroesophageal reflux disease: A multicenter cross-sectional study. World J Gastroenterol 2025; 31(45): 113060 [PMID: 41378325 DOI: 10.3748/wjg.v31.i45.113060]

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