Dialister-driven succinate accumulation is associated with disease activity and postoperative recurrence in Crohn’s disease

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Dec 7, 2025; 31(45): 112618
Published online Dec 7, 2025. doi: 10.3748/wjg.v31.i45.112618

Table 2 Significant bacterial species identified as succinate producers or consumers in the study cohort

Non-IBD vs inactive CD	P value	Non-IBD vs active CD	P value	Active vs inactive CD	P value
Succinate-producers
Paraprevotella clara	6.09E-06	Prevotella buccae	1.18E-10	Prevotella buccae	5.76E-07
Bacteroides intestinalis	3.95E-03	Roseburia hominis	6.15E-09	Prevotella copri	2.01E-06
Escherichia coli	3.01E-02	Fusobacterium nucleatum	8.20E-09	Fusobacterium nucleatum	7.22E-06
Parabacteroides johnsonii	3.37E-02	Campylobacter concisus	2.29E-07	Campylobacter concisus	2.50E-05
Faecalibacterium prausnitzii	4.38E-02	Escherichia coli	4.32E-04	Escherichia coli	6.09E-03
		Paraprevotella clara	6.91E-07	Bacteroides vulgatus	9.25E-03
		Bifidobacterium adolescentis	1.58E-06	Citrobacter freundii	9.26E-03
		Prevotella copri	5.58E-05	Parabacteroides johnsonii	9.89E-03
		Faecalibacterium prausnitzii	7.51E-04
		Citrobacter freundii	1.89E-03
Succinate-consumers
Phascolarctobacterium faecium	4.46E-03	Dialister pneumosintes	6.72E-09	Dialister pneumosintes	6.25E-06
Dialister invisus	2.80E-02			Phascolarctobacterium faecium	1.73E-03

CD: Crohn’s disease; IBD: Inflammatory bowel disease.

Citation: Boronat-Toscano A, Queipo-Ortuño MI, Monfort-Ferré D, Suau R, Vañó-Segarra I, Valldosera G, Cepero C, Astiarraga B, Clua-Ferré L, Plaza-Andrade I, Aranega-Martín L, Cabrinety L, Abadia de Barbarà C, Castellano-Castillo D, Moliné A, Caro A, Domènech E, Sánchez-Herrero JF, Benaiges-Fernandez R, Fernández-Veledo S, Vendrell J, Ginés I, Sumoy L, Manyé J, Menacho M, Serena C. Dialister-driven succinate accumulation is associated with disease activity and postoperative recurrence in Crohn’s disease. World J Gastroenterol 2025; 31(45): 112618
URL: https://www.wjgnet.com/1007-9327/full/v31/i45/112618.htm
DOI: https://dx.doi.org/10.3748/wjg.v31.i45.112618

Boronat-Toscano A, Queipo-Ortuño MI, Monfort-Ferré D, Suau R, Vañó-Segarra I, Valldosera G, Cepero C, Astiarraga B, Clua-Ferré L, Plaza-Andrade I, Aranega-Martín L, Cabrinety L, Abadia de Barbarà C, Castellano-Castillo D, Moliné A, Caro A, Domènech E, Sánchez-Herrero JF, Benaiges-Fernandez R, Fernández-Veledo S, Vendrell J, Ginés I, Sumoy L, Manyé J, Menacho M, Serena C. Dialister-driven succinate accumulation is associated with disease activity and postoperative recurrence in Crohn’s disease. World J Gastroenterol 2025; 31(45): 112618 [PMID: 41378335 DOI: 10.3748/wjg.v31.i45.112618]

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