Transient elastography and fibrosis-4 index as predictors of hepatocellular carcinoma in hepatitis C virus patients with sustained virological response

Table 4 Cox regression models regarding post-treatment liver stiffness measure and fibrosis-4 index as continuous or categorical variables

Covariates	HR (95%CI)	P value
Model 4a: LSM, kPa
Sex (male)	1.17 (0.57-2.42)	0.66
1-year-EOT LSM, kPa	1.04 (1.01-1.06)	< 0.001
Age at 1-year-EOT, years	1.04 (0.99-1.08)	0.05
Model 4b: LSM ≥ 20 kPa
Sex (male)	1.45 (0.71-2.95)	0.30
1-year-EOT LSM ≥ 20 kPa	4.49 (2.19-9.19)	< 0.001
Age at 1-year-EOT, years	1.04 (1.003-1.085)	0.03
Model 4c: FIB-4 index
Sex (male)	1.10 (0.60-2.01)	0.30
Age at 1-year-EOT, years	1.040 (1.002-1.080)	0.04
1-year-EOT FIB-4 index	1.16 (1.06-1.28)	< 0.001
Model 4d: FIB-4 index ≥ 3.25
Sex (male)	1.15 (0.63-2.09)	0.63
Age at 1-year-EOT, years	1.03 (0.99-1.07)	0.07
1-year-EOT FIB-4 index ≥ 3.25	3.14 (1.65-6.00)	< 0.001

HR: Hazard ratio; CI: Confidence interval; LSM: Liver stiffness measure; 1-year-EOT: One year after the end of treatment; FIB-4: Fibrosis-4.