Transient elastography and fibrosis-4 index as predictors of hepatocellular carcinoma in hepatitis C virus patients with sustained virological response

Table 3 Cox regression models regarding pre-treatment liver stiffness measure and fibrosis-4 index as continuous or categorical variables

Covariates	HR (95%CI)	P value
Model 3a: LSM, kPa
Sex (male)	1.42 (0.63-3.2)	0.39
Pre-treatment LSM, kPa	1.05 (1.02-1.07)	< 0.001
Pre-treatment age, years	1.06 (1.01-1.11)	0.10
Model 3b: LSM ≥ 20 kPa
Sex (male)	0.72 (0.32-1.63)	0.43
Pre-treatment LSM ≥ 20 kPa	0.2 (0.08-0.47)	< 0.001
Pre-treatment age, years	1.06 (1.01-1.11)	0.02
Model 3c: FIB-4 index
Sex (male)	1.41 (0.57-3.49)	0.45
Pre-treatment age, years	1.06 (1.01-1.11)	0.22
Pre-treatment FIB-4 index	1.13 (1.05-1.21)	< 0.001
Model 3d: FIB-4 index ≥ 3.25
Sex (male)	1.81 (0.49-2.82)	0.71
Pre-treatment age, years	1.06 (1-1.11)	0.034
Pre-treatment FIB-4 index ≥ 3.25	7.79 (2.31-26.32)	< 0.001

HR: Hazard ratio; CI: Confidence interval; LSM: Liver stiffness measure; FIB-4: Fibrosis-4.