Retreatment hepatitis B surface antigen clearance prediction model identifies pegylated interferon alpha candidates in chronic hepatitis B

doi:10.3748/wjg.v31.i44.112719

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Cohort Study

World J Gastroenterol. Nov 28, 2025; 31(44): 112719
Published online Nov 28, 2025. doi: 10.3748/wjg.v31.i44.112719

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Figure 4 Stratified hepatitis B surface antigen clearance rates by retreatment hepatitis B surface antigen clearance prediction score categories. Patients were categorized using optimal cutoffs (74 and 110): Retreatment hepatitis B surface antigen clearance prediction score (RHCP-S) challenge group (< 74, clearance 3.45%); RHCP-S probable group (74-110, 29.63%), and RHCP-S dominant group (≥ 110, 80.95%). Bar heights represent cumulative clearance rates, demonstrating significant gradient efficacy (P < 0.001). HBsAg: Hepatitis B surface antigen; RHCP-S: Retreatment hepatitis B surface antigen clearance prediction score; RS-CG: Retreatment hepatitis B surface antigen clearance prediction score-challenge group; RS-PG: Retreatment hepatitis B surface antigen clearance prediction score-probable group; RS-DG: Retreatment hepatitis B surface antigen clearance prediction score-dominant group.

Citation: Fu YC, Li J, Wang JY, Zhang YW, Yan F, Chen J, Du Q, Yang C, Liang J, Ye Q, Xiang HL. Retreatment hepatitis B surface antigen clearance prediction model identifies pegylated interferon alpha candidates in chronic hepatitis B. World J Gastroenterol 2025; 31(44): 112719
URL: https://www.wjgnet.com/1007-9327/full/v31/i44/112719.htm
DOI: https://dx.doi.org/10.3748/wjg.v31.i44.112719

Fu YC, Li J, Wang JY, Zhang YW, Yan F, Chen J, Du Q, Yang C, Liang J, Ye Q, Xiang HL. Retreatment hepatitis B surface antigen clearance prediction model identifies pegylated interferon alpha candidates in chronic hepatitis B. World J Gastroenterol 2025; 31(44): 112719 [PMID: 41356529 DOI: 10.3748/wjg.v31.i44.112719]

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