DNA polymerase epsilon-mutant colorectal cancers: Insights into non-exonuclease domain mutation variants, microsatellite instability status, and co-mutation profiles

Table 5 Stratified descriptive statistics of DNA polymerase epsilon-mutant colorectal cancer patients by age, tumor location, and microsatellite instability status, including all co-mutations, n (%)

POLE mutation	Patient (n)	MSI-H	MSS/MSI-L	Co-mutation	OR MSI-H	95%CI	Colon (n)	Rectum (n)	Age (n)
									< 50 years	50-65 years	> 65 years
EDM	2	0 (0)	2 (100)	-	0.03	0.001 to -1.2	2	0	1	1	0
Non-EDM	189	23 (12.17)	166 (87.83)	BRAF, ERCC5, KRAS, MLH3, MSH3, MSH6, PIK3CA, PMS2, TCF7 L2, TP53	1 (reference)	-	150	39	50	100	39
Total	191	23 (12.04)	168 (87.96)	-	-	-	152	39	51	101	39

The most frequent 10 co-mutations are listed. CI: Confidence interval; EDM: Exonuclease domain mutation; MSI: Microsatellite instability; MSI-H: High microsatellite instability; MSI-L: Low microsatellite instability; MSS: Microsatellite-stable; OR: Odds ratio; POLE: DNA polymerase epsilon.