DNA polymerase epsilon-mutant colorectal cancers: Insights into non-exonuclease domain mutation variants, microsatellite instability status, and co-mutation profiles

doi:10.3748/wjg.v31.i44.112524

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Nov 28, 2025; 31(44): 112524
Published online Nov 28, 2025. doi: 10.3748/wjg.v31.i44.112524

Table 4 Distribution of DNA polymerase epsilon mutation type and microsatellite instability status

POLE mutation type	Total patients (n)	MSI-H (n)	MSS/MSI-L (n)	P value
EDM mutation	2	0	2
Non-EDM mutation	189	23	166
Total	191	23	168	P = 1.0

EDM: Exonuclease domain mutation; MSI-H: High microsatellite instability; MSI-L: Low microsatellite instability; MSS: Microsatellite-stable; POLE: DNA polymerase epsilon.

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Citation: Taskiran I, Orenay-Boyacioglu S, Boyacioglu O, Erdogdu IH, Culhaci N, Meteoglu I. DNA polymerase epsilon-mutant colorectal cancers: Insights into non-exonuclease domain mutation variants, microsatellite instability status, and co-mutation profiles. World J Gastroenterol 2025; 31(44): 112524
URL: https://www.wjgnet.com/1007-9327/full/v31/i44/112524.htm
DOI: https://dx.doi.org/10.3748/wjg.v31.i44.112524

Taskiran I, Orenay-Boyacioglu S, Boyacioglu O, Erdogdu IH, Culhaci N, Meteoglu I. DNA polymerase epsilon-mutant colorectal cancers: Insights into non-exonuclease domain mutation variants, microsatellite instability status, and co-mutation profiles. World J Gastroenterol 2025; 31(44): 112524 [PMID: 41356525 DOI: 10.3748/wjg.v31.i44.112524]

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