Diagnostic performance of serum origin recognition complex subunit 1 protein for hepatitis B virus-related hepatocellular carcinoma

Figure 6 Schematic model illustrating the molecular mechanism and diagnostic workflow of hepatitis B virus integration near origin recognition complex subunit 1 and extra spindle pole bodies-like 1. The hepatitis B virus S gene integrates near the origin recognition complex subunit 1 and extra spindle pole bodies-like 1 loci, promoting their overexpression. These genes may be co-regulated in hepatitis B virus-related hepatocellular carcinoma. Since origin recognition complex subunit 1 controls the S phase while extra spindle pole bodies-like 1 regulates the M phase, their concurrent dysregulation could drive aberrant cell cycle progression, leading to hepatocyte aneuploidy and malignant transformation. ORC1: Origin recognition complex subunit 1; ESPL1: Extra spindle pole bodies-like 1; HBV: Hepatitis B virus.