Diagnostic performance of serum origin recognition complex subunit 1 protein for hepatitis B virus-related hepatocellular carcinoma

Figure 4 Detection of hepatitis B-related hepatocellular carcinoma cases by alpha-fetoprotein, origin recognition complex subunit 1, and extra spindle pole bodies-like 1 among alpha-fetoprotein-negative patients. A: Among 90 hepatitis B-related hepatocellular carcinomas (HBV-HCC) cases, 71 (78.9%) were alpha-fetoprotein (AFP)-negative; B: Among these AFP-negative cases, serum extra spindle pole bodies-like 1 and origin recognition complex subunit 1 identified 52 (73.2%) and 46 (64.8%) cases, respectively; C: Serum origin recognition complex subunit 1 levels were significantly elevated in both AFP-negative and AFP-positive HBV-HCC patients compared to healthy controls (P < 0.05); D: Serum extra spindle pole bodies-like 1 levels were significantly higher in AFP-negative and AFP-positive HBV-HCC patients than in healthy controls (P < 0.001). ESPL1: Extra spindle pole bodies-like 1; HBV-HCC: Hepatitis B virus-related hepatocellular carcinoma; ORC1: Origin recognition complex subunit 1; AFP: Alpha-fetoprotein; NS: Not significant.