Diagnostic performance of serum origin recognition complex subunit 1 protein for hepatitis B virus-related hepatocellular carcinoma

doi:10.3748/wjg.v31.i44.112481

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Nov 28, 2025; 31(44): 112481
Published online Nov 28, 2025. doi: 10.3748/wjg.v31.i44.112481

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Figure 1 Hepatitis B virus S gene integration cluster near the human origin recognition complex subunit 1 gene locus on chromosome 1 (Chr1 1p32. 3). Genome-wide analysis of hepatitis B virus (HBV) integration in 15 HBV-related hepatocellular carcinoma tumor tissues revealed 14 cases with HBV-human integration. Among these, 10 (71.4%) harbored integration events clustered within a 6 Mb region centered around the origin recognition complex subunit 1 gene (indicated by orange dashed box). A representative case showed HBV S gene integration at the origin recognition complex subunit 1 promoter region. ORC1: Origin recognition complex subunit 1; HBV: Hepatitis B virus.

Citation: Feng YF, Su TM, Hu BB, Wang H, Li QM, Yin QB, Huang L, Liang HQ, Ren AL, Su MH, Jiang JN. Diagnostic performance of serum origin recognition complex subunit 1 protein for hepatitis B virus-related hepatocellular carcinoma. World J Gastroenterol 2025; 31(44): 112481
URL: https://www.wjgnet.com/1007-9327/full/v31/i44/112481.htm
DOI: https://dx.doi.org/10.3748/wjg.v31.i44.112481

Feng YF, Su TM, Hu BB, Wang H, Li QM, Yin QB, Huang L, Liang HQ, Ren AL, Su MH, Jiang JN. Diagnostic performance of serum origin recognition complex subunit 1 protein for hepatitis B virus-related hepatocellular carcinoma. World J Gastroenterol 2025; 31(44): 112481 [PMID: 41356527 DOI: 10.3748/wjg.v31.i44.112481]

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