Diagnostic performance of serum origin recognition complex subunit 1 protein for hepatitis B virus-related hepatocellular carcinoma

doi:10.3748/wjg.v31.i44.112481

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Nov 28, 2025; 31(44): 112481
Published online Nov 28, 2025. doi: 10.3748/wjg.v31.i44.112481

Table 5 Diagnostic reliability analysis of serum biomarkers for hepatitis B virus-related hepatocellular carcinoma, (n/N, %)

Group	Sensitivity	Specificity	Accuracy	PPV	NPV
ORC1	65.56 (59/90, 0.551-0.750)	54.84 (170/310, 0.493-0.603)	57.25 (229/400, 0.523-0.621)	29.65 (59/199, 0.235-0.365)	84.58 (170/201, 0.792-0.889)
ESPL1	71.11 (64/90, 0.612-0.798)	86.77 (269/310, 0.827-0.901)	83.25 (333/400, 0.792-0.868)	60.95 (64/105, 0.514-0.697)	91.19 (269/295, 0.876-0.939)
AFP	21.11 (19/90, 0.138-0.309)	100.00 (310/310, 0.988-1.000)	82.25 (329/400, 0.782-0.858)	100.00 (19/19, 0.824-1.000)	81.36 (310/381, 0.773-0.849)
ORC1 + ESPL1 + AFP	84.44^a^,^b (76/90, 0.756-0.909)	84.19^c (261/310, 0.798-0.879)	84.25^c (337/400, 0.803-0.876)	60.80 (76/125, 0.521-0.690)	94.91 (261/275, 0.917-0.971)

^aP < 0.05 vs ESPL1.

^bP < 0.05 vs AFP.

^cP < 0.05 vs ORC1.

PPV: Positive predictive value; NPV: Negative predictive value; ORC1: Origin recognition complex subunit 1; ESPL1: Extra spindle pole bodies-like 1; AFP: Alpha-fetoprotein.

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Citation: Feng YF, Su TM, Hu BB, Wang H, Li QM, Yin QB, Huang L, Liang HQ, Ren AL, Su MH, Jiang JN. Diagnostic performance of serum origin recognition complex subunit 1 protein for hepatitis B virus-related hepatocellular carcinoma. World J Gastroenterol 2025; 31(44): 112481
URL: https://www.wjgnet.com/1007-9327/full/v31/i44/112481.htm
DOI: https://dx.doi.org/10.3748/wjg.v31.i44.112481

Feng YF, Su TM, Hu BB, Wang H, Li QM, Yin QB, Huang L, Liang HQ, Ren AL, Su MH, Jiang JN. Diagnostic performance of serum origin recognition complex subunit 1 protein for hepatitis B virus-related hepatocellular carcinoma. World J Gastroenterol 2025; 31(44): 112481 [PMID: 41356527 DOI: 10.3748/wjg.v31.i44.112481]

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