Diagnostic performance of serum origin recognition complex subunit 1 protein for hepatitis B virus-related hepatocellular carcinoma

doi:10.3748/wjg.v31.i44.112481

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Nov 28, 2025; 31(44): 112481
Published online Nov 28, 2025. doi: 10.3748/wjg.v31.i44.112481

Table 4 Receiver operating characteristic curve analysis of serum biomarkers in the diagnosis of hepatitis B virus-related hepatocellular carcinoma

Group	AUC	Youden’s index	Cut-off value	95%CI	Z value	P value
ORC1	0.587	0.204	967.814	0.520-0.653	2.599	0.012
ESPL1	0.776^b	0.579	345.654	0.713-0.893	8.547	< 0.001
AFP	0.844^b	0.566	400.000	0.794-0.984	13.498	< 0.001
ORC1 + ESPL1 + AFP	0.887^a^,^b	0.686	0.152	0.784-0.891	17.541	< 0.001

^aP < 0.05 vs ESPL1.

^bP < 0.05 vs ORC1.

AUC: Area under the curve; CI: Confidence interval; ORC1: Origin recognition complex subunit 1; ESPL1: Extra spindle pole bodies-like 1; AFP: Alpha-fetoprotein.

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Citation: Feng YF, Su TM, Hu BB, Wang H, Li QM, Yin QB, Huang L, Liang HQ, Ren AL, Su MH, Jiang JN. Diagnostic performance of serum origin recognition complex subunit 1 protein for hepatitis B virus-related hepatocellular carcinoma. World J Gastroenterol 2025; 31(44): 112481
URL: https://www.wjgnet.com/1007-9327/full/v31/i44/112481.htm
DOI: https://dx.doi.org/10.3748/wjg.v31.i44.112481

Feng YF, Su TM, Hu BB, Wang H, Li QM, Yin QB, Huang L, Liang HQ, Ren AL, Su MH, Jiang JN. Diagnostic performance of serum origin recognition complex subunit 1 protein for hepatitis B virus-related hepatocellular carcinoma. World J Gastroenterol 2025; 31(44): 112481 [PMID: 41356527 DOI: 10.3748/wjg.v31.i44.112481]

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