Role of artificial intelligence in the detection and characterization of gastrointestinal premalignant and early malignant lesions

Table 7 Summary of randomized controlled trials on computer aided detection for the detection of colorectal polyps[151-159,166,175-178,230-235]

Ref.	Study design	Number of patients	Country	Outcomes (AI vs control)
Wang et al[151]	Single center RCT	1058	China	ADR: 29% vs 20%
Wang et al[156]	Single center RCT (double blind)	962	China	ADR: 34% vs 28%
Gong et al[157]	Single center RCT	704	China	ADR: 16% vs 8%
Su et al[158]	Single center RCT	659	China	ADR: 29% vs 17%
Liu et al[159]	RCT	1026	China	ADR: 39% vs 23%
Wang et al[175]	Tandem RCT	369	China	AMR: 14% vs 40%
Repici et al[152]	Multicenter RCT	685	Italy	ADR: 55% vs 40%
Kamba et al[176]	Tandem RCT	358	Japan	AMR: 14% vs 37%
Glissen Brown et al[177]	Multicenter tandem RCT	223	United States	AMR: 20% vs 31%
Repici et al[153]	RCT	660	Italy, Switzerland	ADR: 53% vs 45%
Wallace et al[178]	Tandem RCT	240	Italy, United Kingdom, United States	AMR: 16% vs 32%
Shaukat et al[166]	RCT	1359	United States	APC: 1 vs 0.8
Xu et al[230]	Multicenter RCT	3059	China	ADR: 40% vs 32%
Gimeno-García et al[231]	Single center RCT	370	Spain	ADR: 55% vs 41%
Nakashima et al[154]	Single center RCT	415	Japan	ADR: 59% vs 48%
Karsenti et al[232]	Single center RCT	2592	France	ADR: 38% vs 34%
Lau et al[155]	Single center RCT	766	China	ADR: 58% vs 45%
Maas et al[233]	Multicenter RCT	916	Germany, Netherlands, United States, Israel	ADR: AI 37% vs 30%
Thiruvengadam et al[234]	Single center RCT	1100	United States	ADR: 43% vs 34%
Park et al[235]	Multicenter RCT	805	Korea	ADR: 35% vs 28%

AI: Artificial intelligence; ADR: Adenoma detection rate; AMR: Adenoma miss rate; APC: Adenoma per colonoscopy; RCT: Randomized controlled trial.