Distal small bowel resection with preservation of the terminal ileum suppresses hepatic gluconeogenesis via the Prevotellaceae_NK3B31_group-mediated 7-KLCA-FXR axis

doi:10.3748/wjg.v31.i43.112483

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Nov 21, 2025; 31(43): 112483
Published online Nov 21, 2025. doi: 10.3748/wjg.v31.i43.112483

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Figure 6 Mechanism diagram of improved glucose metabolism after distal bowel resection with preservation of the terminal ileum surgery. 7-KLCA: 7-ketolithocholic acid; FXR: Farnesoid X receptor; GLP-1: Glucagon-like peptide 1; G6PC: Glucose-6-phosphatase; PCK1: Phosphoenolpyruvate carboxykinase 1.

Citation: Xu CY, Zheng ZH, Yang K, Wu RR, Cao JQ, Duan JY. Distal small bowel resection with preservation of the terminal ileum suppresses hepatic gluconeogenesis via the Prevotellaceae_NK3B31_group-mediated 7-KLCA-FXR axis. World J Gastroenterol 2025; 31(43): 112483
URL: https://www.wjgnet.com/1007-9327/full/v31/i43/112483.htm
DOI: https://dx.doi.org/10.3748/wjg.v31.i43.112483

Xu CY, Zheng ZH, Yang K, Wu RR, Cao JQ, Duan JY. Distal small bowel resection with preservation of the terminal ileum suppresses hepatic gluconeogenesis via the Prevotellaceae_NK3B31_group-mediated 7-KLCA-FXR axis. World J Gastroenterol 2025; 31(43): 112483 [PMID: 41358181 DOI: 10.3748/wjg.v31.i43.112483]

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