Distal small bowel resection with preservation of the terminal ileum suppresses hepatic gluconeogenesis via the Prevotellaceae_NK3B31_group-mediated 7-KLCA-FXR axis

Figure 5 Significant changes in fecal bile acid profiles after distal bowel resection with preservation of the terminal ileum surgery are correlated with the expression levels of gluconeogenic key enzyme genes. A: Changes in fecal bile acid profiles of rats at 6 weeks post-surgery; B: Correlation between bile acids, glucagon-like peptide-1, and gluconeogenic key enzyme genes; C: Expression changes of CYP7A1, CYP27A1, and CYP8B1 in the liver; D: Correlation analysis. Data are presented as mean ± SEM, and statistical significance was determined by two-tailed Student's t-test or two-way ANOVA. ^aP < 0.05, ^bP < 0.01, ^cP < 0.001. TBA: Total serum bile acid; HCA: Hyocholic acid; α-MCA: Α-muricholic acid; DCA: Deoxycholic acid; UDCA: Ursodeoxycholic acid; GCA: Glycocholic acid; 7-KLCA: 7-ketolithocholic acid; LCA: Lithocholic acid; DBRPI: Distal bowel resection with preservation of the terminal ileum; GLP-1: Glucagon-like peptide-1; CDCA: Chenodeoxycholic acid.