Distal small bowel resection with preservation of the terminal ileum suppresses hepatic gluconeogenesis via the Prevotellaceae_NK3B31_group-mediated 7-KLCA-FXR axis

Figure 1 Distal bowel resection with preservation of the terminal ileum reduces body weight and improves glucose tolerance in a time-dependent manner. A: Changes in body weight; B: Changes in fasting blood glucose; C: Postprandial blood glucose in serum; D: Glycated serum protein; E: Area under the curve of the oral glucose tolerance test (OGTT); F: OGTT before surgery and at 2, 4, and 6 weeks after surgery. n = 6 for distal bowel resection with preservation of the terminal ileum, n = 6 for Sham. Data are presented as mean ± SEM, and statistical significance was determined by two-tailed Student's t-test or two-way ANOVA. ^aP < 0.05, ^bP < 0.01, ^cP < 0.001. DBRPI: Distal bowel resection with preservation of the terminal ileum; FBG: Fasting blood glucose; AUC-OGTT: Area under the curve of the oral glucose tolerance test; OGTT: Oral glucose tolerance test; PBG: Postprandial blood glucose; GSP: Glycated serum protein.