Repeat ablation and single-session ablation in patients with multiple colorectal cancer liver metastases after chemotherapy failure

Table 3 Association between lesion characteristics and progression-free survival-univariate analysis

Variables	Totally		Single		Repeat
	HR (95%CI)	P value	HR (95%CI)	P value	HR (95%CI)	P value
Sex	1.3 (0.64-2.6)	0.35	1.4 (0.55-3.7)	0.47	1.1 (0.39-3.3)	0.81
Age	1 (0.97-1)	0.92	1 (0.96-1)	0.89	1 (0.95-1.1)	0.62
Size (max, cm)	2.2 (1.5-3.1)	0.000a	1.7 (1-3)	0.05a	3.8 (1.9-8)	0.000a
Quantity	NA	NA	1.5 (0.88-2.7)	0.13	1.2 (1.0-1.5)	0.041a
Time	1.1 (0.78-1.6)	0.52	NA	NA	1.8 (0.98-0.31)	0.047a
Colon/rectum	0.52 (0.26-1.0)	0.062	0.54 (0.21-1.4)	0.21	0.51 (0.19-1.4)	0.2
Pathological differentiation	0.89 (0.37-2.1)	0.80	1.2 (0.4-3.6)	0.76	0.37 (0.079-1.7)	0.21
Hepatectomy1	20.51 (0.20-1.27)1	0.11	0.77 (0.20-2.97)1	0.69	0.41 (0.12-1.40)1	0.114
Extrahepatic metastases
Regional	1.3 (0.68-2.5)	0.41	1.6 (0.64-3.9)	0.33	0.91 (0.29-2.8)	0.87
Distant1	4.39 (1.73-11.15)1	0.007a	4.29 (1.4-12.74)1	0.019a	5.77(0.93-36.0)1	0.106

¹Hazard ratio: Small sample sizes adjusted via Firth regression.

^aP < 0.05.

NA: Not available; HR: Hazard ratio; CI: Confidence interval.