Targeting pyroptosis in inflammatory bowel disease: A potentially effective therapeutic approach

Figure 4 Targeting the nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 inflammasome pathway: Mechanisms and therapeutic inhibitors. NLRP3: Nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3; IL: Interleukin; TLR: Toll-like receptor; NF-κB: Nuclear factor kappa-B; GSDMD: Gasdermin D; IL-1R: Interleukin-1 receptor; IL-18R: Interleukin-18 receptor; ASC: Adapter protein apoptosis-associated speck-like protein containing a CARD; ASO: Antisense oligonucleotide; siRNA: Small interfering RNA.