Targeting pyroptosis in inflammatory bowel disease: A potentially effective therapeutic approach

Figure 1 Canonical and non-canonical activation pathways of pyroptosis. NLRP3: Nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3; PAMP: Pathogen-associated molecular pattern; DAMP: Damage-associated molecular pattern; LPS: Lipopolysaccharide; TLR: Toll-like receptor; NF-κB: Nuclear factor kappa-B; ASC: Adapter protein apoptosis-associated speck-like protein containing a CARD; HAMP: Homeostasis-altering molecular processes; ROS: Reactive oxygen species; mtDNA: Mitochondrial DNA; IL: Interleukin.