Multistrain probiotics alleviate gastrointestinal symptoms during bismuth quadruple therapy for Helicobacter pylori infection

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Randomized Controlled Trial

World J Gastroenterol. Nov 14, 2025; 31(42): 112577
Published online Nov 14, 2025. doi: 10.3748/wjg.v31.i42.112577

Table 3 Changes in the gastrointestinal symptom scores of the study participants after intervention, mean ± SD

Variables	Intervention group (n = 89)	Placebo-controlled group (n = 85)	Z	P value
GSRS score after 2 weeks of intervention - baseline GSRS score
Reflux syndrome_2-0	-3.06 ± 1.50	-2.58 ± 1.26	2.243	0.025^a
Abdominal pain syndrome_2-0	-1.25 ± 2.11	-1.46 ± 2.68	0.016	0.987
Dyspepsia_2-0	-3.00 ± 3.66	-2.58 ± 3.17	0.801	0.423
Diarrhea_2-0	-1.70 ± 3.74	-1.87 ± 2.83	-0.831	0.406
Constipation_2-0	-1.62 ± 3.08	-1.62 ± 2.93	-0.164	0.870
GSRS total score_2-0	-8.63 ± 9.54	-8.11 ± 8.30	0.495	0.620
GSRS score after 4 weeks of intervention - baseline GSRS score
Reflux syndrome_4-0	-3.09 ± 1.41	-2.64 ± 1.34	-1.933	0.053
Abdominal pain syndrome_4-0	-1.93 ± 2.39	-1.58 ± 2.68	-0.754	0.451
Dyspepsia_4-0	-3.89 ± 3.87	-2.45 ± 3.59	-1.813	0.070
Diarrhea_4-0	-2.90 ± 3.21	-1.60 ± 2.77	-2.458	0.014^a
Constipation_4-0	-1.74 ± 2.54	-1.14 ± 2.87	-1.525	0.127
GSRS total score_4-0	-13.55 ± 9.26	-9.40 ± 8.46	-2.356	0.018^a
GSRS score after 8 weeks of intervention - baseline GSRS score
Reflux syndrome_8-0	-3.00 ± 1.41	-2.62 ± 1.64	-1.365	0.172
Abdominal pain syndrome_8-0	-2.02 ± 2.32	-1.60 ± 3.04	-1.350	0.177
Dyspepsia_8-0	-4.19 ± 3.75	-2.59 ± 3.20	-2.381	0.017^a
Diarrhea_8-0	-2.98 ± 3.31	-1.83 ± 2.62	-1.846	0.065
Constipation_8-0	-1.87 ± 3.02	-1.36 ± 3.00	-1.316	0.188
GSRS total score_8-0	-14.06 ± 9.32	-10.00 ± 8.56	-2.279	0.023^a

^aP < 0.05.

GSRS total score: The sum of the scores of the 5 dimensions, with higher scores indicating more severe symptoms.

Citation: Liu WJ, Zhao YM, Xie QQ, Wu MC, Pan YF, Yan HK, Shan XX, Xu WT, Liu YL, Peng CX, Zhang XM, Lin Q. Multistrain probiotics alleviate gastrointestinal symptoms during bismuth quadruple therapy for Helicobacter pylori infection. World J Gastroenterol 2025; 31(42): 112577
URL: https://www.wjgnet.com/1007-9327/full/v31/i42/112577.htm
DOI: https://dx.doi.org/10.3748/wjg.v31.i42.112577

Liu WJ, Zhao YM, Xie QQ, Wu MC, Pan YF, Yan HK, Shan XX, Xu WT, Liu YL, Peng CX, Zhang XM, Lin Q. Multistrain probiotics alleviate gastrointestinal symptoms during bismuth quadruple therapy for Helicobacter pylori infection. World J Gastroenterol 2025; 31(42): 112577 [PMID: 41278159 DOI: 10.3748/wjg.v31.i42.112577]

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