Clinical predictors of multidrug-resistant Gram-negative pyogenic liver abscess and nomogram construction: A retrospective analysis

Table 3 Univariate logistic regression analysis and multivariate stepwise regression analysis

Variables	Univariate analysis	Multivariate analysis	Variables	Univariate analysis
	OR (95%CI)	P value	OR (95%CI)	P value
Age ≥ 60 years	2.248 (1.360-3.718)	0.002	1.957 (1.099-3.484)	0.023
Female sex	1.320 (0.784-2.220)	0.296
BMI	0.895 (0.830-0.964)	0.003	0.936 (0.866-1.011)	0.092
Diabetes	1.454 (0.877-2.411)	0.147	1.998 (1.089-3.663)	0.025
Hypertension	0.983 (0.565-1.711)	0.953
Malignant tumor	4.522 (2.309-8.857)	< 0.001	3.968 (1.810-8.699)	< 0.001
Charlson Comorbidity Index	1.357 (1.193-1.543)	< 0.001
laboratory examination
White blood cell count (× 109/L)	1.001 (0.964-1.040)	0.961
Absolute lymphocyte count (× 109/L)	0.912 (0.585-1.421)	0.822
Neutrophil count (× 109/L)	1.003 (0.965-1.043)	0.866
Neutral-lymphocyte ratio	1.002 (0.985-1.019)	0.811
Hemoglobin (g/L)	0.970 (0.956-0.983)	< 0.001
Platelet count (× 109/L)	0.999 (0.998-1.001)	0.509
CRP (mg/L)	0.996 (0.993-0.999)	0.013	0.993 (0.990-0.997)	0.001
ALT (U/L)	0.997 (0.994-1.000)	0.036
AST (U/L)	0.998 (0.996-1.000)	0.094	0.998 (0.995-1.000)	0.082
GGT (U/L)	1.001 (1.000-1.003)	0.088	1.002 (1.000-1.004)	0.081
Albumin (g/L)	0.954 (0.915-0.996)	0.030	0.955 (0.907-1.004)	0.073
Total bilirubin	1.000 (0.992-1.008)	0.951
APTT (seconds)	1.016 (0.962-1.074)	0.567	1.058 (0.978-1.145)	0.157
PT (seconds)	1.026 (0.988-1.066)	0.180	1.065 (1.007-1.127)	0.028
PCT (ng/mL)	0.997 (0.988-1.007)	0.550
IL-6 (pg/mL)	1.000 (1.000-1.000)	0.674
Imaging results
Abscess size (mm)	0.992 (0.984-1.001)	0.076
Abscess location
Right lobe
Left lobe	0.685 (0.336-1.399)	0.300
Bilateral	1.074 (0.414-2.781)	0.884
Multiple abscesses	1.614 (0.957-2.721)	0.073
Co-existing with other infections
Pulmonary infection	0.700 (0.414-1.185)	0.185	0.562 (0.303-1.044)	0.068
Comorbidities
Septic shock	1.185 (0.537-2.618)	0.674
Pleural effusion	1.133 (0.658-1.951)	0.653
Ascites	1.604 (0.615-4.183)	0.334
Biliary tract diseases	2.442 (1.455-4.099)	< 0.001
Heart failure	0.691 (0.233-2.048)	0.505
Renal insufficiency	0.765 (0.254-2.304)	0.634

BMI: Body mass index; CRP: C-reactive protein; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; GGT: Gamma-glutamyl transferase; APTT: Activated partial thromboplastin time; PCT: Procalcitonin; PT: Prothrombin time; IL-6: Interleukin-6; CI: Confidence interval; OR: Odds ratio.