Predicting chemotherapy-induced myelosuppression in colorectal cancer: An interpretable, machine learning-based nomogram

Figure 2 Sample size calculation flowchart. rMPSE: Root mean squared prediction error; MPSE: Mean squared prediction error; EPV: Events per variable. In formula: Ø: Events fraction; δ: A margin of error, generally recommend < 0.05; P: Number of candidate predictors; S: Shrinkage factor; R²_cs: A (conservative) value for the anticipated model performance is required, as defined by the Cox-Snell R squared statistic; MAPE: The mean absolute prediction error; n: The sample size.