Thymosin β4 released by mast cells under stress conditions impairs intestinal epithelial barrier via IL22RA1/JAK1/STAT3 signaling in irritable bowel syndrome

doi:10.3748/wjg.v31.i42.111706

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Nov 14, 2025; 31(42): 111706
Published online Nov 14, 2025. doi: 10.3748/wjg.v31.i42.111706

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Figure 10 Graphical abstract. Mast cell-released thymosin β4 drives intestinal barrier dysfunction in stress-induced irritable bowel syndrome. Tβ4: Thymosin β4; CRH: Corticotropin-releasing hormone; CRHR1: Corticotropin-releasing hormone receptor 1; JAK1: Janus kinase 1; STAT3: Signal transducer and activation of transcription 3; MC: Mast cell; MLCK: Myosin light chain kinase; IL22RA1: Interleukin 22 receptor A1; IBS: Irritable bowel syndrome.

Citation: Sun YS, Bai XQ, Sun KD, Li J, Liu L, Chen YY, Zeng ZY, Wang Q, Guo YB. Thymosin β4 released by mast cells under stress conditions impairs intestinal epithelial barrier via IL22RA1/JAK1/STAT3 signaling in irritable bowel syndrome. World J Gastroenterol 2025; 31(42): 111706
URL: https://www.wjgnet.com/1007-9327/full/v31/i42/111706.htm
DOI: https://dx.doi.org/10.3748/wjg.v31.i42.111706

Sun YS, Bai XQ, Sun KD, Li J, Liu L, Chen YY, Zeng ZY, Wang Q, Guo YB. Thymosin β4 released by mast cells under stress conditions impairs intestinal epithelial barrier via IL22RA1/JAK1/STAT3 signaling in irritable bowel syndrome. World J Gastroenterol 2025; 31(42): 111706 [PMID: 41278163 DOI: 10.3748/wjg.v31.i42.111706]

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