Could artificial intelligence-powered colonoscopies change the future of colorectal cancer screening?

Table 1 Trials using computer-aided detection system for colorectal lesions[86-108]

Ref.	Year	Application used	Patients (n)	Findings
Wang et al[86]	2019	Endo Screener	1058	AI system significantly increased ADR (29.1% vs 20.3%; P < 0.001)
Su et al[87]	2019	AQCS	623	AI significantly increased ADR (28.9% vs 16.5%; P < 0.001)
Liu et al[88]	2020	Henan Tongyu	1026	AI significantly increased ADR (39% vs 24%; P < 0.001)
Gong et al[89]	2020	ENDOANGEL	704	AI significantly increased ADR (16% vs 8%; P = 0.001)
Repici et al[90]	2020	GI genius	685	AI significantly increased ADR (54.8% vs 40.4%)
Wang et al[91]	2020	Endo Screener	369	AMR was significantly lower with AI (13.9% vs 40.0%; P < 0.001)
Wang et al[92]	2020	Endo Screener	962	AI system significantly increased ADR rather than the sham system (34% vs 28%; P = 0.030)
Kamba et al[93]	2021	Endo Screener	358	AMR was significantly lower with AI (13.8% vs 40.6%; P < 0.001)
Xu et al[94]	2021	Endo Screener	2325	AI system did not significantly increase PDR (38.8% vs 36.2%; P = 0.183)
Luo et al[95]	2021	Endo Screener	150	AI system significantly increased PDR (38.7% vs 34.0%; P < 0.001)
Shaukat et al[96]	2022	Endo Screener	1359	AI system significantly increased adenomas per colonoscopy (1.05 vs 0.83; P = 0.002)
Wallace et al[97]	2022	GI genius	230	AMR was significantly lower with AI (15.5% vs 32.4%; P < 0.001)
Glissen Brown et al[98]	2022	Endo Screener	223	AMR was significantly lower with AI than with high-definition white light colonoscopy (20.12% vs 31.25%; P = 0.025)
Lui et al[99]	2023	Endo Screener	216	AI significantly increased ADR in proximal colon (44.7% vs 34.6%)
Ahmad et al[100]	2023	GI genius	614	AI system did not significantly increase ADR (71.4% vs 65.0%; P = 0.09)
Mangas-Sanjuan et al[101]	2023	GI genius	3213	AI system did not significantly increase advanced colorectal neoplasia detection rate (34.8% vs 34.6%; P = 0.91)
Karsenti et al[102]	2023	GI genius	2015	AI system slightly increased ADR (37.5% vs 33.7%; P = 0.051)
Wei et al[103]	2023	Endo Vigilant	769	AI system did not significantly increase ADR (35.9% vs 37.2%; P = 0.774)
Nakashima et al[104]	2023	CAD EYE	415	AI system significantly increased ADR (59.4% vs 47.6%; P = 0.018)
Gimeno-García et al[105]	2024	ENDO-AID	370	AI system significantly increased ADR (55.1% vs 43.8%; P = 0.029)
Yao et al[106]	2024	ENDOANGEL	685	AMR was significantly lower with AI (18.82% vs 43.69%; P < 0.001)
Schöler et al[107]	2024	CAD EYE	286	AI system did not significantly increase ADR (43% vs 41%; P = 0.696)
Yamaguchi et al[108]	2024	CAD EYE	231	AMR was significantly lower with AI (25.6% vs 38.6%; P = 0.033)

AQCS: Automatic quality control system; GI: Gastrointestinal; CAD: Computer-aided diagnosis; ENDO-AID: Endoscopy computer-aided diagnosis system; AI: Artificial intelligence; ADR: Adenoma detection rate; PDR: Polyp detection rate; AMR: Adenoma miss rate.