Precision therapy guided by genotypic antibiotic resistance for Helicobacter pylori eradication: A prospective, randomized controlled trial

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Randomized Controlled Trial

World J Gastroenterol. Nov 14, 2025; 31(42): 110717
Published online Nov 14, 2025. doi: 10.3748/wjg.v31.i42.110717

Table 2 Clinical and demographic characteristics of the studied groups, n (%)

Baseline characteristics	BQT group (n = 97)	G-AST group (n = 97)	P value	χ²/t/z
Age (years), mean ± SD	52.81 ± 10.69	50.20 ± 9.45	0.072	1.808
Gender (male)	46 (47.4)	48 (49.5)	0.083	0.774
Height (m), mean ± SD	1.67 ± 0.08	1.68 ± 0.09	0.230	-1.2
Weight (kg), mean ± SD	66.14 ± 10.56	68.24 ± 11.62	0.189	-1.318
BMI, mean ± SD	23.73 ± 2.89	24.08 ± 3.24	0.432	-0.787
Smoking	20 (20.6)	14 (14.4)	0.257	1.284
Alcohol consumption	22 (22.7)	22 (22.7)	1.0	0
Hypertension	23 (23.7)	19 (19.6)	0.486	0.486
Diabetes	22 (22.7)	13 (13.4)	0.093	2.824
Family history of gastric cancer	11 (11.3)	13 (13.4)	0.663	0.190
Bile reflux	10 (10.3)	15 (15.5)	0.284	1.148
Atrophic gastritis	63 (64.9)	52 (53.6)	0.108	2.584

BMI: Body mass index; G-AST: Genotypic antibiotic susceptibility testing; BQT: Bismuth quadruple therapy.

Citation: Xu Y, Hao JW, Min CC, Yang L, Ma CP, Shi C, Mao T, Tian ZB, Wang T, Yu YN. Precision therapy guided by genotypic antibiotic resistance for Helicobacter pylori eradication: A prospective, randomized controlled trial. World J Gastroenterol 2025; 31(42): 110717
URL: https://www.wjgnet.com/1007-9327/full/v31/i42/110717.htm
DOI: https://dx.doi.org/10.3748/wjg.v31.i42.110717

Xu Y, Hao JW, Min CC, Yang L, Ma CP, Shi C, Mao T, Tian ZB, Wang T, Yu YN. Precision therapy guided by genotypic antibiotic resistance for Helicobacter pylori eradication: A prospective, randomized controlled trial. World J Gastroenterol 2025; 31(42): 110717 [PMID: 41278167 DOI: 10.3748/wjg.v31.i42.110717]

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