Hepatoprotective effects of silybin in liver fibrosis

Figure 2 Key biological and pharmacological properties of silybin. This figure highlights the major therapeutic properties of silybin, the principal active constituent of silymarin extracted from Silybum marianum (milk thistle). Silybin exerts strong antioxidant and anti-inflammatory effects, primarily through the modulation of oxidative stress, suppression of pro-inflammatory cytokines, regulation of apoptotic pathways, and inhibition of fibrogenic signaling. These multifaceted actions contribute to its hepatoprotective and antifibrotic potential. ROS: Reactive oxygen species; SOD: Superoxidedismutase.