Early vs conventional initiation of adjuvant chemotherapy in advanced gastric cancer: A propensity-matched outcomes study

doi:10.3748/wjg.v31.i42.110069

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Cohort Study

World J Gastroenterol. Nov 14, 2025; 31(42): 110069
Published online Nov 14, 2025. doi: 10.3748/wjg.v31.i42.110069

Table 4 Multivariate Cox regression for recurrence-free survival

Variable	HR for recurrence	95%CI	P value
Early vs conventional	1.199	0.461-3.121	0.710
Tumor differentiation
Differentiated (reference¹)	1
Undifferentiated	2.071	0.929-4.618	0.075
BMI, kg/m²
< 23 (reference¹)	1
≥ 23	0.523	0.176-1.554	0.244
Chemotherapy regimen
SOX (reference)	1
XELOX	0.767	0.325-1.809	0.545
mFOLFOX6	0.919	0.144-5.878	0.929

¹The reference category in the Cox model.

HR: Hazard ratio; CI: Confidence interval; BMI: Body mass index; SOX: Tegafur plus oxaliplatin; XELOX: Capecitabine plus oxaliplatin; mFOLFOX-6: 5-fluorouracil plus calcium folinate plus oxaliplatin.

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Citation: Lin L, Zhang P, Wang YY, Cai YF, Wen LB, Chen WP, Xiao YF, Li ZK, Liu GY. Early vs conventional initiation of adjuvant chemotherapy in advanced gastric cancer: A propensity-matched outcomes study. World J Gastroenterol 2025; 31(42): 110069
URL: https://www.wjgnet.com/1007-9327/full/v31/i42/110069.htm
DOI: https://dx.doi.org/10.3748/wjg.v31.i42.110069

Lin L, Zhang P, Wang YY, Cai YF, Wen LB, Chen WP, Xiao YF, Li ZK, Liu GY. Early vs conventional initiation of adjuvant chemotherapy in advanced gastric cancer: A propensity-matched outcomes study. World J Gastroenterol 2025; 31(42): 110069 [PMID: 41278157 DOI: 10.3748/wjg.v31.i42.110069]

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