HLA-C*03:04:01 and HLA-B*15:18:01 but not HLA-DQA1*05 associated with anti- tumor necrosis factor antibody formation in Taiwanese inflammatory bowel disease patients

doi:10.3748/wjg.v31.i41.111745

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Nov 7, 2025; 31(41): 111745
Published online Nov 7, 2025. doi: 10.3748/wjg.v31.i41.111745

Table 3 Frequency of anti-drug antibody associated human leukocyte antigen alleles in Taiwanese inflammatory bowel disease patients and the general population, %

HLA	IBD (n = 190)	Control (n = 2194)	P value
HLA-C*03:04:01	8.4	10.5	0.3701
HLA-B*15:18:01	1.6	0.6	0.1484
HLA-DQA1*05	25.3	19.8	0.0749

IBD: Inflammatory bowel disease; HLA: Human leukocyte antigen.

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Citation: Weng MT, Yao CY, Lin WC, Lai SK, Tung CC, Wang CY, Wong JM, Chen PL, Wei SC. HLA-C*03:04:01 and HLA-B*15:18:01 but not HLA-DQA1*05 associated with anti- tumor necrosis factor antibody formation in Taiwanese inflammatory bowel disease patients. World J Gastroenterol 2025; 31(41): 111745
URL: https://www.wjgnet.com/1007-9327/full/v31/i41/111745.htm
DOI: https://dx.doi.org/10.3748/wjg.v31.i41.111745

Weng MT, Yao CY, Lin WC, Lai SK, Tung CC, Wang CY, Wong JM, Chen PL, Wei SC. HLA-C03:04:01 and HLA-B*15:18:01 but not HLA-DQA1*05 associated with anti- tumor necrosis factor antibody formation in Taiwanese inflammatory bowel disease patients. World J Gastroenterol* 2025; 31(41): 111745 [PMID: 41257274 DOI: 10.3748/wjg.v31.i41.111745]

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