Risk assessment of type I gastric neuroendocrine tumors based on endoscopic and clinical features of autoimmune gastritis

Table 3 Comparison of laboratory test indicators between autoimmune gastritis patients with or without gastric neuroendocrine tumors, n (%)/mean ± SD/median (interquartile range)

Variables	Total (n = 303)	Non-gNETs group (n = 187)	gNETs group (n = 116)	P value	Missing
PCA				0.019a	9 (2.97)
Positive (≥ 1:160)	144 (48.8)	89 (49.7)	55 (47.4)
Weak positive (1:100)	129 (43.7)	71 (39.7)	58 (50)
Negative (< 1:100)	22 (7.5)	19 (10.6)	3 (2.6)
IFAb (AU/mL)				0.572	11 (3.63)
Positive (≥ 1.53)	135 (46.2)	85 (47.5)	50 (44.2)
Weak positive (1.2-1.53)	63 (21.6)	35 (19.6)	28 (24.8)
Negative (< 1.2)	94 (32.2)	59 (33)	35 (31)
Gastrin-17 (pmol/L)	51.3 (6.9, 64.4)	55.3 (40.0, 71.4)	49.8 (35.3, 62.1)	0.257	229 (75.58)
Vitamin B12 (pmol/L)				< 0.001b	22 (7.26)
≤ 133	184 (64.3)	96 (55.8)	88 (77.2)
133-223	41 (14.3)	27 (15.7)	14 (12.3)
> 223	61 (21.3)	49 (28.5)	12 (10.5)
TPOAb or TGAb positive	111 (51.9)	52 (50)	59 (53.6)	0.595	89 (29.37)
Other antibody positive	50 (17.0)	37 (20.6)	13 (11.4)	0.042a	9 (2.97)
IFAb (AU/mL)	1.3 (1.2, 32.8)	1.3 (1.2, 57.5)	1.3 (1.2, 11.5)	0.257	11 (3.63)
Vitamin B12 (pmol/L)	124.0 (80.0, 221.0)	152.0 (83.0, 275.0)	102.0 (79.5, 151.2)	< 0.001b	22 (7.26)
Ferritin (ng/mL)	23.1 (9.2, 63.4)	30.6 (9.1, 68.8)	19.6 (9.2, 39.6)	0.077	23 (7.59)
WBC (× 109/L)	5.5 ± 1.6	5.7 ± 1.6	5.3 ± 1.4	0.035a	15 (4.95)
HGB (g/L)	125.1 ± 25.1	122.1 ± 25.9	129.6 ± 23.2	0.012a	9 (2.97)
MCV (fL)	87.7 ± 10.4	88.3 ± 11.9	86.8 ± 7.6	0.208	13 (4.29)
PLT (× 109/L)	224.3 ± 71.2	228.0 ± 75.2	218.9 ± 64.9	0.292	18 (5.94)
PGI (ng/mL)	5.9 (3.5, 9.6)	7.4 (4.3, 16.3)	4.3 (3.0, 7.0)	< 0.001b	110 (36.30)
PGI/II	0.8 (0.6, 1.2)	1.1 (0.6, 1.6)	0.7 (0.5, 0.9)	< 0.001b	112 (36.96)
TSH (μIU/mL)	2.1 (1.3, 3.4)	2.1 (1.5, 3.7)	2.1 (1.3, 3.1)	0.227	86 (28.38)
TPOAb (IU/mL)	26.2 (9.9, 258.0)	20.0 (9.4, 166.0)	53.2 (10.2, 357.8)	0.167	90 (29.70)
TGAb (IU/mL)	24.9 (14.7, 102.8)	23.1 (14.1, 59.7)	25.0 (15.0, 163.2)	0.191	89 (29.37)
HCY (μmol/L)	11.3 (9.1, 15.8)	12.3 (9.1, 17.5)	11.2 (9.1, 14.3)	0.142	149 (49.17)

^aP < 0.05.

^bP < 0.01.

PCA: Parietal cell antibody; IFAb: Intrinsic factor antibody; TPOAb: Thyroid peroxidase antibody; TGAb: Thyroglobulin antibody; WBC: White blood cell; HGB: Hemoglobin; MCV: Mean corpuscular volume; PLT: Platelet count; PGI: Pepsinogen I; PGI/II: Ratio of pepsinogen I to II; TSH: Thyroid-stimulating hormone; HCY: Homocysteine; gNETs: Gastric neuroendocrine tumors.