Mechanisms of ferroptosis in primary hepatocellular carcinoma and progress of artificial intelligence-based predictive modeling in hepatocellular carcinoma

doi:10.3748/wjg.v31.i41.111174

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Nov 7, 2025; 31(41): 111174
Published online Nov 7, 2025. doi: 10.3748/wjg.v31.i41.111174

Table 1 Representative targeted drugs and signaling pathways in liver cancer

Representative targeted drugs	Related signaling pathways
Sorafenib	Ras/Raf/MEK/ERK signaling pathway
Apatinib, lenvatinib, bevacizumab, ramelimumab	VEGF signaling pathway
Erlotinib, cetuximab	EGF signaling pathway
Cabozantinib	HGF/c-Met signaling pathway

Raf: Rapidly accelerated fibrosarcoma; MEK: Mitogen-activated protein kinase kinase; ERK: Extracellular signal-regulated kinase; EGF: Epidermal growth factor; VEGF: Vascular endothelial growth factor; HGF: Hepatocyte growth factor; c-Met: Mesenchymal-epithelial transition factor.

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Citation: Han JF, Jia ZY, Fan X, Zhao XY, Cheng LY, Xia YX, Ji XR, Zang WQ. Mechanisms of ferroptosis in primary hepatocellular carcinoma and progress of artificial intelligence-based predictive modeling in hepatocellular carcinoma. World J Gastroenterol 2025; 31(41): 111174
URL: https://www.wjgnet.com/1007-9327/full/v31/i41/111174.htm
DOI: https://dx.doi.org/10.3748/wjg.v31.i41.111174

Han JF, Jia ZY, Fan X, Zhao XY, Cheng LY, Xia YX, Ji XR, Zang WQ. Mechanisms of ferroptosis in primary hepatocellular carcinoma and progress of artificial intelligence-based predictive modeling in hepatocellular carcinoma. World J Gastroenterol 2025; 31(41): 111174 [PMID: 41257281 DOI: 10.3748/wjg.v31.i41.111174]

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