Insights into the GALAD score: A new optimal cut-off for hepatocellular carcinoma

doi:10.3748/wjg.v31.i40.111727

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Oct 28, 2025; 31(40): 111727
Published online Oct 28, 2025. doi: 10.3748/wjg.v31.i40.111727

Table 3 Performance of the GALAD score using healthy individuals or patients with cirrhosis as reference

Response variable	AUC	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)	Accuracy (%)
Control (Ref.)
HCC	0.9725; (K-fold = 0.9743); Δ = 0.0018	85.23	98.86	94.94	96.40	96.14
Cirrhosis (Ref.)
HCC	0.8609; (K-fold = 0.8657); Δ = 0.0048	47.73	95.28	76.36	85.09	83.77

Δ was calculated as difference between area under the curve after K-fold and area under the curve calculated with classical approach. AUC: Area under the curve; PPV: Positive predictive value; NPV: Negative predictive value; HCC: Hepatocellular carcinoma.

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Citation: Villa E, Donghia R, Coletta S, Bonfiglio C, Critelli RM, Ancona A, Shahini E, Iacovazzi PA, Cozzolongo R, Pavone F, Carella N, Pontisso P, Martini A, Al Aoua S, Bantel H, Giannelli G. Insights into the GALAD score: A new optimal cut-off for hepatocellular carcinoma. World J Gastroenterol 2025; 31(40): 111727
URL: https://www.wjgnet.com/1007-9327/full/v31/i40/111727.htm
DOI: https://dx.doi.org/10.3748/wjg.v31.i40.111727

Villa E, Donghia R, Coletta S, Bonfiglio C, Critelli RM, Ancona A, Shahini E, Iacovazzi PA, Cozzolongo R, Pavone F, Carella N, Pontisso P, Martini A, Al Aoua S, Bantel H, Giannelli G. Insights into the GALAD score: A new optimal cut-off for hepatocellular carcinoma. World J Gastroenterol 2025; 31(40): 111727 [PMID: 41180985 DOI: 10.3748/wjg.v31.i40.111727]

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