Growth differentiation factor 11 modulates metabolism, mitigating the pro-tumoral behavior provided by M2-like macrophages in hepatocellular carcinoma-derived cells

Figure 8 Cytokine profile changes induced by growth differentiation factor 11 on post M2-like macrophages. A: Interleukin and interferon family alteration by growth differentiation factor 11 (GDF11) on post M2-like macrophages, ^aP < 0.0001 vs post M2-like conditioned media (CM), ^bP = 0.0012 vs post M2-like CM; B: Chemokine family alteration by GDF11 on post M2-like macrophages, ^aP < 0.0001 vs post M2-like CM, ^bP = 0.0050 vs post M2-like CM; C: Growth factors alteration by GDF11 on post M2-like macrophages, ^aP ≤ 0.0001 vs post M2-like CM. The mean pixel density in each column on the heat map represents the mean ± SEM of at least three independent experiments. CM: Conditioned media; GDF11: Growth differentiation factor 11.