Sequential changes of antibiotic resistances of Helicobacter pylori in Taiwan from 2019 to 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Study

World J Gastroenterol. Oct 21, 2025; 31(39): 111380
Published online Oct 21, 2025. doi: 10.3748/wjg.v31.i39.111380

Table 3 Dual resistances in Helicobacter pylori treatment-naive patients from 2019 to 2024 in Taiwan

	Year	Patient number	Proportion, % (95%CI)	P value (χ² test for linear trend)
Amoxicillin + clarithromycin	2019	0/256	0 (0.0-0.0)	0.720
	2020	2/330	0.6 (0.0-1.0)
	2021	0/159	0 (0.0-0.0)
	2022	1/299	0.3 (0.0-1.1)
	2023	0/249	0 (0.0-0.0)
	2024	1/115	0.9 (0.0-2.9)
Amoxicillin + metronidazole	2019	0/256	0 (0.0-0.0)	0.543
	2020	5/330	1.5 (0.3-3.0)
	2021	2/159	1.3 (0.0-3.2)
	2022	1/299	0.3 (0.0-1.1)
	2023	0/249	0.0 (0.0-0.0)
	2024	1/115	0.9 (0.0-2.9)
Amoxicillin + tetracycline	2019	0/256	0.0 (0.0-0.0)	0
	2020	0/330	0.0 (0.0-0.0)
	2021	0/159	0.0 (0.0-0.0)
	2022	0/299	0.0 (0.0-0.0)
	2023	0/249	0.0 (0.0-0.0)
	2024	0/115	0.0 (0.0-0.0)
Clarithromycin + metronidazole	2019	20/256	7.8 (4.5-11.1)	0.208
	2020	23/330	7.0 (4.2-9.7)
	2021	10/159	6.3 (2.5-10.1)
	2022	21/299	7.0 (4.1-9.9)
	2023	14/249	5.6 (2.7-8.5)
	2024	5/115	4.3 (0.6-8.1)
Clarithromycin + tetracycline	2019	0/256	0.0 (0.0-0.0)	0.013
	2020	0/330	0.0 (0.0-0.0)
	2021	0/159	0.0 (0.0-0.0)
	2022	2/299	0.7 (0.0-1.7)
	2023	1/249	0.4 (0.0-1.3)
	2024	2/115	1.7 (0.0-4.5)
Metronidazole + tetracycline	2019	0/256	0.0 (0.0-0.0)	0.007
	2020	0/330	0.0 (0.0-0.0)
	2021	1/159	0.6 (0.0-2.1)
	2022	2/299	0.7 (0.0-1.7)
	2023	3/249	1.2 (0.0-2.8)
	2024	2/115	1.7 (0.0-4.5)

CI: Confidence interval.

Citation: Wu PJ, Tsay FW, Wu DC, Yang JC, Chuah SK, Chen KY, Chen CL, Lee CL, Shih CA, Liu YH, Shiu SI, Tai WC, Kuo CH, Lei WY, Kao SS, Tsai TJ, Feng IC, Koseki M, Hsu PI, Sheu MJ. Sequential changes of antibiotic resistances of Helicobacter pylori in Taiwan from 2019 to 2024. World J Gastroenterol 2025; 31(39): 111380
URL: https://www.wjgnet.com/1007-9327/full/v31/i39/111380.htm
DOI: https://dx.doi.org/10.3748/wjg.v31.i39.111380

Wu PJ, Tsay FW, Wu DC, Yang JC, Chuah SK, Chen KY, Chen CL, Lee CL, Shih CA, Liu YH, Shiu SI, Tai WC, Kuo CH, Lei WY, Kao SS, Tsai TJ, Feng IC, Koseki M, Hsu PI, Sheu MJ. Sequential changes of antibiotic resistances of Helicobacter pylori in Taiwan from 2019 to 2024. World J Gastroenterol 2025; 31(39): 111380 [PMID: 41180781 DOI: 10.3748/wjg.v31.i39.111380]

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