Sequential changes of antibiotic resistances of Helicobacter pylori in Taiwan from 2019 to 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Oct 21, 2025; 31(39): 111380
Published online Oct 21, 2025. doi: 10.3748/wjg.v31.i39.111380

Table 2 Antibiotic resistances in Helicobacter pylori treatment-naive patients from 2019 to 2024 in Taiwan

	Year	Patient number	Proportion, % (95%CI)	P value (χ² test for linear trend)
Amoxicillin	2019	0/256	0.0 (0.0-0.0)	0.289
	2020	7/330	2.1 (0.6-3.7)
	2021	4/159	2.5 (0.1-5.0)
	2022	1/299	0.3 (0.0-1.0)
	2023	1/249	0.4 (0.0-1.2)
	2024	5/115	4.3 (0.6-8.1)
Clarithromycin	2019	37/256	14.5 (10.1-18.8)	0.514
	2020	65/330	19.7 (15.4-24.0)
	2021	33/159	20.8 (14.4-27.1)
	2022	56/299	18.7 (14.3-23.3)
	2023	34/249	13.7 (9.4-17.9)
	2024	28/115	24.3 (16.4-32.3)
Metronidazole	2019	91/256	35.5 (29.6-41.4)	0.000
	2020	118/330	35.8 (30.5-41.0)
	2021	52/159	32.7 (25.3-40.1)
	2022	86/299	28.8 (23.6-33.9)
	2023	75/249	30.1 (24.4-35.9)
	2024	15/115	13.0 (6.8-19.3)
Tetracycline	2019	0/256	0.0 (0.0-0.0)	0.000
	2020	0/330	0.0 (0.0-0.0)
	2021	1/159	0.6 (0.0-2.0)
	2022	3/299	1.0 (0.0-2.3)
	2023	3/249	1.2 (0.0-2.8)
	2024	4/115	3.5 (0.1-7.2)
Levofloxacin	2019	81/256	31.6 (25.9-37.3)	0.269
	2020	91/330	27.6 (22.7-32.4)
	2021	57/159	35.8 (28.3-43.4)
	2022	76/299	25.4 (20.5-30.4)
	2023	64/249	25.7 (20.2-31.2)
	2024	35/115	30.4 (21.9-39.0)

CI: Confidence interval.

Citation: Wu PJ, Tsay FW, Wu DC, Yang JC, Chuah SK, Chen KY, Chen CL, Lee CL, Shih CA, Liu YH, Shiu SI, Tai WC, Kuo CH, Lei WY, Kao SS, Tsai TJ, Feng IC, Koseki M, Hsu PI, Sheu MJ. Sequential changes of antibiotic resistances of Helicobacter pylori in Taiwan from 2019 to 2024. World J Gastroenterol 2025; 31(39): 111380
URL: https://www.wjgnet.com/1007-9327/full/v31/i39/111380.htm
DOI: https://dx.doi.org/10.3748/wjg.v31.i39.111380

Wu PJ, Tsay FW, Wu DC, Yang JC, Chuah SK, Chen KY, Chen CL, Lee CL, Shih CA, Liu YH, Shiu SI, Tai WC, Kuo CH, Lei WY, Kao SS, Tsai TJ, Feng IC, Koseki M, Hsu PI, Sheu MJ. Sequential changes of antibiotic resistances of Helicobacter pylori in Taiwan from 2019 to 2024. World J Gastroenterol 2025; 31(39): 111380 [PMID: 41180781 DOI: 10.3748/wjg.v31.i39.111380]

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