Early risk stratification of post-endoscopic retrograde cholangiopancreatography pancreatitis using 4-hour serum amylase and lipase: A prospective study

Table 3 Diagnostic performance of 4-hour and 24-hour amylase and lipase for post-endoscopic retrograde cholangiopancreatography pancreatitis prediction

Variables	Time point	AUC	Cut-off (IU/L)	Sensitivity	Specificity	PPV	NPV	AUC difference (4 hours-24 hours, 95%CI)	P value
Amylase	4-hour	0.877	119.5	0.846	0.806	0.221	0.988	-0.087 (-0.124 to -0.049)	< 0.001
	24-hour	0.963	301	0.957	0.942	0.519	0.997
Lipase	4-hour	0.893	488.5	0.863	0.862	0.287	0.990	-0.061 (-0.095 to -0.027)	< 0.001
	24-hour	0.954	443	0.897	0.927	0.443	0.993

The upper normal limit was defined as 100 IU/L for serum amylase and 60 IU/L for serum lipase. AUC: Area under the curve; PPV: Positive predictive value; NPV: Negative predictive value; CI: Confidence interval.