Targetable pathways for drug repurposing in gastric cancer

Figure 4 Mechanisms of action of repurposed drugs targeting the Wnt, nuclear factor kappa B, and Hippo signaling pathways. Purple form indicated main pathway proteins; light blue form indicated drugs; dark blue form indicated proteins involved in the mechanism of action of the drug; “?” symbol indicated target is not clear. β-AR: Beta-adrenergic receptor; NF-κB: Nuclear factor kappa B; DKK1: Dickkopf-related protein 1; YAP: Yes-associated protein; TAZ: Transcriptional coactivator with PDZ-binding motif; HMGCR: Hydroxymethyl glutaryl-CoA.