Targetable pathways for drug repurposing in gastric cancer

doi:10.3748/wjg.v31.i39.110986

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Oct 21, 2025; 31(39): 110986
Published online Oct 21, 2025. doi: 10.3748/wjg.v31.i39.110986

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Figure 1 Mechanisms of action of repurposed drugs targeting the mitogen-activated protein kinase signaling pathway. Purple form indicated main pathway proteins; light blue form indicated drugs; dark blue form indicated proteins involved in the mechanism of action of the drug; “?” symbol indicated target is not clear. KLF: Krupple-like factor; DDIT4: DNA damage inducible transcript 4; MEK: Mitogen-activated protein; ERK: Extracellular signal-regulated kinase; MAPK: Mitogen-activated protein kinase.

Citation: Valero-Almingol A, Montori S, Felípez N, Santamaría E, Fernandez-Irigoyen J, Luzko I, Cuestas AA, Pardo C, Prat R, Moreira L, Albéniz E. Targetable pathways for drug repurposing in gastric cancer. World J Gastroenterol 2025; 31(39): 110986
URL: https://www.wjgnet.com/1007-9327/full/v31/i39/110986.htm
DOI: https://dx.doi.org/10.3748/wjg.v31.i39.110986

Valero-Almingol A, Montori S, Felípez N, Santamaría E, Fernandez-Irigoyen J, Luzko I, Cuestas AA, Pardo C, Prat R, Moreira L, Albéniz E. Targetable pathways for drug repurposing in gastric cancer. World J Gastroenterol 2025; 31(39): 110986 [PMID: 41180788 DOI: 10.3748/wjg.v31.i39.110986]

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