Lysine acetyltransferase 2A-mediated succinylation of adenosine monophosphate-activated protein kinase suppresses gallstone formation by inhibiting inflammation and pyroptosis

doi:10.3748/wjg.v31.i39.110115

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Oct 21, 2025; 31(39): 110115
Published online Oct 21, 2025. doi: 10.3748/wjg.v31.i39.110115

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Figure 7 The molecular mechanism diagram. Down-regulation of lysine acetyltransferase 2A reduces adenosine monophosphate-activated protein kinase (AMPK) succinylation. Reduced AMPK succinylation inhibits the interaction between AMPK and liver kinase B1, thereby suppressing AMPK phosphorylation. Inhibition of AMPK phosphorylation promotes pyroptosis and inflammation in gallbladder mucosal epithelial cells, ultimately leading to gallstone formation. TNF-α: Tumor necrosis factor; IL: Interleukin; suc: Succinylation; GMECs: Gallbladder mucosal epithelial cells.

Citation: Wang XX, Ma MZ, Zhu LC, Dai LF, Qin C, Shao S, Xu XW, Gao RX, Zhang ZH. Lysine acetyltransferase 2A-mediated succinylation of adenosine monophosphate-activated protein kinase suppresses gallstone formation by inhibiting inflammation and pyroptosis. World J Gastroenterol 2025; 31(39): 110115
URL: https://www.wjgnet.com/1007-9327/full/v31/i39/110115.htm
DOI: https://dx.doi.org/10.3748/wjg.v31.i39.110115

Wang XX, Ma MZ, Zhu LC, Dai LF, Qin C, Shao S, Xu XW, Gao RX, Zhang ZH. Lysine acetyltransferase 2A-mediated succinylation of adenosine monophosphate-activated protein kinase suppresses gallstone formation by inhibiting inflammation and pyroptosis. World J Gastroenterol 2025; 31(39): 110115 [PMID: 41180789 DOI: 10.3748/wjg.v31.i39.110115]

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