Lysine acetyltransferase 2A-mediated succinylation of adenosine monophosphate-activated protein kinase suppresses gallstone formation by inhibiting inflammation and pyroptosis

Figure 6 Lysine acetyltransferase 2A overexpression inhibited the apoptosis and the inflammation in gallbladder mucosal epithelial cells. A: Body weight of each group (n = 6); B: Biliary bile cholesterol saturation index; C: Total bile acids content; D: Total cholesterol (TC) content in bile of each group were measured (n = 6); E: Enzyme-linked immunosorbent assay analysis of the concentrations alanine aminotransferase; F: Aspartate aminotransferase; G: Alkaline phosphatase; H: TC; I: Total triglycerides; J: High density lipoprotein cholesterol; K: Low density lipoprotein cholesterol; L: Tumor necrosis factor-α; M: Interleukin (IL)-1β; N: IL-18 (n = 6); O: Representive image of gallbladder stones of each group mice; P: Histological examination of each group gallbladder by hematoxylin and eosin staining. KAT2A: Lysine acetyltransferase 2A.