Clinical features of early esophageal neoplastic lesions at different stages and efficacy and prognosis after endoscopic submucosal dissection

Table 4 Efficacy and safety of endoscopic mucosal dissection in esophageal tumors of varying differentiation, n (%)

	LGIN (n = 71, 26.9%)	HGIN (n = 97, 36.7%)	Early cancer (n = 65, 24.6%)	Superficial cancer (n = 31, 11.7%)	P value
Short-term outcomes
Absolute indication	71 (100)b,c,d	88 (90.7)a,c,d	26 (40.0)a,b,d	0 (0)a,b,c	< 0.001
R0 resection	71 (100)c,d	92 (94.8)d	56 (86.2)a	22 (71.0)a,b	< 0.001
CR	71 (100)c,d	92 (94.8)d	55 (84.6)a,d	16 (51.6)a,b,c	< 0.001
Muscle layer injury	3 (4.2)d	13 (13.4)	8 (12.3)	9 (29.0)a	0.008
Complications	4 (5.6)c,d	17 (17.5)	16 (24.6)a	12 (38.7)a	< 0.001
Bleeding	0 (0)	3 (3.1)	0 (0)	0 (0)	0.363
Perforation	1 (0)	0 (0)	0 (0)	1 (3.2)	0.198
Stricture	3 (4.2)c,d	14 (14.4)	16 (24.6)a	11 (35.5)a	< 0.001
Long-term outcomes
BMI (kg/m2)	24.22 (22.76-25.60)b,c,d	23.04 (20.95-24.95)a	23.53 (20.57-24.73)a	21.97 (18.94-23.00)a	< 0.001
Adverse outcomes	1 (2.8)c,d	6 (6.2)d	8 (12.3)a	6 (19.4)a,b	0.006
Recurrence	0 (0)c,d	3 (3.1)d	4 (6.2)a	4 (12.9)a,b	0.014
Metastasis	0 (0)	1 (1.0)	1 (1.5)	0 (0)	0.802
Mortality	1 (1.4)	2 (2.1)	5 (7.7)	2 (6.5)	0.133
Multiple primary cancers	11 (15.5)	13 (13.4)	11 (16.9)	5 (16.1)	0.933

^aP < 0.05 vs low-grade intraepithelial neoplasia.

^bP < 0.05 vs high-grade intraepithelial neoplasia.

^cP < 0.05 vs early cancer.

^dP < 0.05 vs superficial cancer.

LGIN: Low-grade intraepithelial neoplasia; HGIN: High-grade intraepithelial neoplasia; CR: Curative resection; BMI: Body mass index.