Clinical features of early esophageal neoplastic lesions at different stages and efficacy and prognosis after endoscopic submucosal dissection

doi:10.3748/wjg.v31.i38.110557

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 31, Issue 38

This Article

(70)

(58)

(0)

(21)

(1093)

(4)

Peer-Review Report of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Study

World J Gastroenterol. Oct 14, 2025; 31(38): 110557
Published online Oct 14, 2025. doi: 10.3748/wjg.v31.i38.110557

Table 3 Pathological characteristics of esophageal mucosal tumors with different degrees of differentiation, n (%)

	LGIN (n = 71)	HGIN (n = 97)	Early cancer (n = 65)	Superficial cancer (n = 31)	P value
Lesion location					0.033
Upper 1/3	18 (25.4)^b	9 (9.3)^a	10 (15.4)	2 (6.5)
Middle 1/3	36 (50.7)	48 (49.5)	34 (52.3)	14 (45.2)
Lower 1/3	17 (23.9)	40 (41.2)	21 (32.3)	15 (48.4)
Lesion length (cm)					< 0.001
≤ 2	46 (64.8)^b^,^c^,^d	25 (25.8)^a	12 (18.5)^a	9 (29.0)^a
> 2 and < 5	22 (31.0)^b^,^c	58 (59.8)^a	37 (56.9)^a	14 (45.2)
≥ 5	3 (4.2)^c^,^d	14 (14.4)	16 (24.6)^a	8 (25.8)^a
Circumferential extent					< 0.001
< 1/2	59 (83.1)^b^,^c^,^d	60 (61.9)^a	31 (47.7)^a	17 (54.8)^a
≥ 1/2 and < 3/4	12 (16.9)	27 (27.8)	16 (24.6)	3 (9.7)
≥ 3/4	0 (0)^b^,^c^,^d	10 (10.3)^a^,^c^,^d	18 (27.7)^a^,^b	11 (35.5)^a^,^b
Invasion depth					< 0.001
M1	71 (100)^c^,^d	97 (100)^c^,^d	0 (0)^a^,^b	0 (0)^a^,^b
M2	0 (0)^c	0 (0)^c	36 (55.4)^a^,^b^,^d	1 (3.2)^c
M3	0 (0)^c^,^d	0 (0)^c^,^d	29 (44.6)^a^,^b^,^d	5 (16.1)^a^,^b^,^c
SM1	0 (0)^d	0 (0)^d	0 (0)^d	23 (74.2)^a^,^b^,^c
SM2	0 (0)	0 (0)	0 (0)	2 (6.5)
Vertical margin					< 0.001
Positive	0 (0)^d	0 (0)^d	4 (6.2)	5 (16.1)^a^,^b
Negative	71 (100)^d	97 (100) ^d	61 (93.8)	26 (83.9)^a^,^b
Horizontal margin					0.001
Positive	0 (0)^d	5 (5.2)	6 (9.2)	6 (19.4)^a
Negative	71 (100)^d	92 (94.8)	59 (90.8)	25 (80.6)^a
Lymphatic invasion					0.364
Positive	0 (0)	0 (0)	1 (1.5)	0 (0)
Negative	71 (100)	97 (100)	64 (98.5)	31 (100)
Vascular invasion					< 0.001
Positive	0 (0)^d	0 (0)^d	0 (0)^d	8 (25.8)^a^,^b^,^c
Negative	71 (100)^d	97 (100)^d	65 (100)^d	23 (74.2)^a^,^b^,^c
Multiple lesions	17 (23.9)^b	7 (7.2)^a	8 (12.3)	6 (19.4)	0.015
Paris classification					0.001
0-I	3 (4.2)	0 (0)	1 (1.5)	0 (0)
0-IIa	4 (5.6)	11 (11.3)	10 (15.4 )	3 (9.7)
0-IIb	59 (83.1)^c^,^d	74 (76.3)	42 (64.6)^a	18 (58.1)^a
0-IIc	5 (7.0)	9 (9.3)	6 (9.2)	3 (9.7)
Mixed type	0 (0)^c^,^d	3 (3.1)^d	7 (10.8)^a	7 (22.6)^a^,^b

^aP < 0.05 vs low-grade intraepithelial neoplasia.

^bP < 0.05 vs high-grade intraepithelial neoplasia.

^cP < 0.05 vs early cancer.

^dP < 0.05 vs superficial cancer.

0-I: Superficial and protruding; 0-IIa: Slightly elevated; 0-IIb: Flat; 0-IIc: Slightly depressed; 0-II: Superficial and excavated (type 0-III); Mixed type: In lesions with combined morphology (e.g., 0-IIa + 0-IIc); M1: Tumor limited to the mucosal epithelium; M2: Tumor limited to the lamina propria without involvement of the muscular mucosa; M3: Tumor involving the muscularis mucosa; SM1: Tumor infiltrated into the superficial submucosa (from the muscularis mucosa to the submucosa < 200 μm); SM2: Tumor involved the deep submucosa (≥ 200 μm in submucosa); LGIN: Low-grade intraepithelial neoplasia; HGIN: High-grade intraepithelial neoplasia.

Full Size Table

Citation: Zhang YM, Zhu N, Chen MY, Li FL, Qin B, Jiang J, Wang SH, Wu J, Quan XJ, Wang CY, Zheng Y, Zou BC. Clinical features of early esophageal neoplastic lesions at different stages and efficacy and prognosis after endoscopic submucosal dissection. World J Gastroenterol 2025; 31(38): 110557
URL: https://www.wjgnet.com/1007-9327/full/v31/i38/110557.htm
DOI: https://dx.doi.org/10.3748/wjg.v31.i38.110557

Zhang YM, Zhu N, Chen MY, Li FL, Qin B, Jiang J, Wang SH, Wu J, Quan XJ, Wang CY, Zheng Y, Zou BC. Clinical features of early esophageal neoplastic lesions at different stages and efficacy and prognosis after endoscopic submucosal dissection. World J Gastroenterol 2025; 31(38): 110557 [PMID: 41112011 DOI: 10.3748/wjg.v31.i38.110557]

All content on this site: Copyright © 1993-2026 Baishideng Publishing Group Inc, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.