Clinical features of early esophageal neoplastic lesions at different stages and efficacy and prognosis after endoscopic submucosal dissection

doi:10.3748/wjg.v31.i38.110557

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Oct 14, 2025; 31(38): 110557
Published online Oct 14, 2025. doi: 10.3748/wjg.v31.i38.110557

Table 1 Clinical and endoscopic features of differentially differentiated esophageal mucosal tumors, n (%)

	LGIN (n = 71)	HGIN (n = 97)	Early cancer (n = 65)	Superficial cancer (n = 31)	P value
Gender					0.818
Male	53 (74.6)	71 (73.2)	44 (67.7)	22 (71.0)
Female	18 (25.4)	26 (26.8)	21 (32.3)	9 (29.0)
Age (years)	61.34 ± 6.94	62.8 ± 8.10	62.91 ± 7.66	61.84 ± 9.06	0.578
Comorbidities
Diabetes	8 (11.3)	10 (10.3)	6 (9.2)	1 (3.2)	0.676
Hypertension	20 (28.2)	24 (24.7)	20 (30.8)	6 (19.4)	0.642
Cardiovascular disease	10 (14.1)	14 (14.4)	7 (10.8)	3 (9.7)	0.873
Liver cirrhosis	8 (11.3)	3 (3.1)	5 (7.7)	1 (3.2)	0.167
Respiratory diseases	7 (9.9)	13 (13.4)	6 (9.2)	8 (25.8)	0.141
Gastroesophageal reflux disease	38 (31.7)	46 (38.3)	26 (40.0)	10 (32.3)	0.174
Barrett's esophagus	3 (4.2)	3 (3.1)	4 (6.2)	0 (0)	0.575
Atrophic gastritis	49 (69.0)	64 (66.0)	43 (66.2)	23 (74.2)	0.836
Hiatal hernia	5 (7.0)	2 (2.1)	2 (3.1)	0 (0)	0.315
Previous tumor history	7 (9.9)	12 (12.4)	8 (12.3)	4 (12.9)	0.943
Previous esophageal cancer history	1 (1.4)	3 (3.1)	0 (0)	2 (6.5)	0.195
Smoking history	28 (39.4)	48 (49.5)	31 (47.7)	19 (61.3)	0.225
Alcohol history	22 (31.0)	32 (33.0)	13 (20.0)	13 (41.9)	0.133
Family history	17 (23.9)	12 (12.4)	5 (7.7)	5 (16.1)	0.055
Accompanying symptoms
Dysphagia	9 (12.7)	13 (13.4)	9 (13.8)	8 (25.8)	0.392
Retrosternal pain	16 (22.5)	26 (26.8)	10 (15.4)	9 (29.0)	0.314
Weight loss	10 (14.1)	12 (12.4)	8 (12.3)	2 (6.5)	0.716
Other	40 (56.3)	51 (52.6)	41 (63.1)	13 (41.9)	0.248
White light endoscopic
Redness	48 (67.6)	72 (74.2)	48 (73.8)	21 (67.7)	0.735
Whitening	11 (15.5)	16 (16.5)	9 (13.8)	4 (12.9)	0.973
Roughness	52 (73.2)	82 (84.5)	47 (72.3)	25 (80.6)	0.194
Erosion	6 (8.5)^c	16 (16.5)	22 (33.8)^a	5 (16.1)	0.002
Nodule	2 (2.8)	7 (7.2)	10 (15.4)	5 (16.1)	0.024
White coating	7 (9.9)	13 (13.4)	11 (16.9)	3 (9.7)	0.640
Submucosal vascular blurring or loss	1 (1.4)^b^,^c	18 (18.6)^a	9 (13.8)^a	3 (9.7)	0.002

^aP < 0.05 vs low-grade intraepithelial neoplasia.

^bP < 0.05 vs high-grade intraepithelial neoplasia.

^cP < 0.05 vs early cancer.

LGIN: Low-grade intraepithelial neoplasia; HGIN: High-grade intraepithelial neoplasia.

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Citation: Zhang YM, Zhu N, Chen MY, Li FL, Qin B, Jiang J, Wang SH, Wu J, Quan XJ, Wang CY, Zheng Y, Zou BC. Clinical features of early esophageal neoplastic lesions at different stages and efficacy and prognosis after endoscopic submucosal dissection. World J Gastroenterol 2025; 31(38): 110557
URL: https://www.wjgnet.com/1007-9327/full/v31/i38/110557.htm
DOI: https://dx.doi.org/10.3748/wjg.v31.i38.110557

Zhang YM, Zhu N, Chen MY, Li FL, Qin B, Jiang J, Wang SH, Wu J, Quan XJ, Wang CY, Zheng Y, Zou BC. Clinical features of early esophageal neoplastic lesions at different stages and efficacy and prognosis after endoscopic submucosal dissection. World J Gastroenterol 2025; 31(38): 110557 [PMID: 41112011 DOI: 10.3748/wjg.v31.i38.110557]

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