Rutaecarpine targets F-box and WD repeat domain containing 11 to inhibit inflammatory infiltration and alleviate acute pancreatitis

Figure 7 Rutaecarpine inhibits F-box and WD repeat domain containing 11 to reduce inflammation and oxidative stress in acute pancreatitis rats. An acute pancreatitis model was established in rats infected with adeno-associated viral -F-box and WD repeat domain containing 11 and treated with rutaecarpine. A-C: Assay kits were used to measure the levels of serum inflammatory factors interleukin-1 beta, interleukin-6, and tumor necrosis factor alpha; D-F: The levels of pancreatic malondialdehyde, superoxide dismutase, and glutathione; G: Immunohistochemistry staining was performed to detect pancreatic CD11b, myeloperoxidase, and Ly6G. n = 5; ^aP < 0.05, ^bP < 0.01, ^cP < 0.001, ^dP < 0.0001. AP: Acute pancreatitis; Rut: Rutaecarpine; AAV-NC: Adeno-associated viral-negative control; FBXW11: F-box and WD repeat domain containing 11; AAV-FBXW11: Adeno-associated viral-F-box and WD repeat domain containing 11; IL-1β: Interleukin-1 beta; IL-6: Interleukin-6; TNF-α: Tumor necrosis factor alpha; MDA: Malondialdehyde; SOD: Superoxide dismutase; GSH: Glutathione; MPO: Myeloperoxidase.