Rutaecarpine targets F-box and WD repeat domain containing 11 to inhibit inflammatory infiltration and alleviate acute pancreatitis

Figure 6 Rutaecarpine inhibits F-box and WD repeat domain containing 11 to reduce tissue injury in acute pancreatitis rats. An acute pancreatitis model was established in rats infected with adeno-associated viral-F-box and WD repeat domain containing 11 and treated with rutaecarpine. A-C: Reverse transcription-quantitative polymerase chain reaction (A) and western blotting (B and C) to detect F-box and WD repeat domain containing 11 mRNA and protein; D: Hematoxylin and eosin staining to detect pancreatic tissue injury; E: Pathology score of pancreas; F and G: Biochemical analysis to determine serum amylase and lipase levels; n = 5; ^aP < 0.05, ^bP < 0.01, ^dP < 0.0001. AAV-NC: Adeno-associated viral-negative control; FBXW11: F-box and WD repeat domain containing 11; AAV-FBXW11: Adeno-associated viral-F-box and WD repeat domain containing 11; AP: Acute pancreatitis; Rut: Rutaecarpine.