Rutaecarpine targets F-box and WD repeat domain containing 11 to inhibit inflammatory infiltration and alleviate acute pancreatitis

Figure 2 Rutaecarpine reduces inflammation and oxidative stress in rats with acute pancreatitis. An acute pancreatitis rat model was established and treated with rutaecarpine. A-C: Assay kits were used to measure the levels of serum inflammatory factors interleukin-1 beta, interleukin-6, and tumor necrosis factor alpha; D-F: The levels of oxidative stress-related malondialdehyde, superoxide dismutase, and glutathione in pancreatic tissue; G: Immunohistochemistry staining was performed to detect CD11b, myeloperoxidase, and Ly6G in pancreatic tissue. n = 5; ^aP < 0.05, ^cP < 0.001, ^dP < 0.0001. AP: Acute pancreatitis; Rut: Rutaecarpine; IL-1β: Interleukin-1 beta; IL-6: Interleukin-6; TNF-α: Tumor necrosis factor alpha; MDA: Malondialdehyde; SOD: Superoxide dismutase; GSH: Glutathione; MPO: Myeloperoxidase.