Prognostic value of serum alpha-fetoprotein kinetics in liver failure on artificial liver support

doi:10.3748/wjg.v31.i37.111914

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Oct 7, 2025; 31(37): 111914
Published online Oct 7, 2025. doi: 10.3748/wjg.v31.i37.111914

Table 7 Relationship between the number of plasma exchange treatments and alpha-fetoprotein levels, mean ± SD

Group	Treatment sessions	AFP increase	P value (within-group¹vs baseline)	P value (between-group²vs other groups)
Low AFP group	4.2 ± 1.5	33.1 ± 10.2	< 0.001	Reference
Medium AFP group	3.5 ± 1.2	57.1 ± 15.6	< 0.001	vs low: 0.003; vs high: 0.012
High AFP group	2.8 ± 1.0	75.1 ± 20.3	< 0.001	vs low: < 0.001; vs medium: 0.009

¹Within-group, significant change from baseline alpha-fetoprotein values.

²Between-group, significant differences in treatment response magnitude between specified groups. P < 0.05 indicates the presence of statistically significant differences.

AFP: Alpha-fetoprotein.

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Citation: Guo WB, Wang LY, Guo XJ, Yang J, Li W, Shen FY, Li YT, Yang JH, Tai WL. Prognostic value of serum alpha-fetoprotein kinetics in liver failure on artificial liver support. World J Gastroenterol 2025; 31(37): 111914
URL: https://www.wjgnet.com/1007-9327/full/v31/i37/111914.htm
DOI: https://dx.doi.org/10.3748/wjg.v31.i37.111914

Guo WB, Wang LY, Guo XJ, Yang J, Li W, Shen FY, Li YT, Yang JH, Tai WL. Prognostic value of serum alpha-fetoprotein kinetics in liver failure on artificial liver support. World J Gastroenterol 2025; 31(37): 111914 [PMID: 41025006 DOI: 10.3748/wjg.v31.i37.111914]

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